cGMP: a second messenger for acetylcholine in the brain?

被引：24

作者：

de Vente, J ^{[1
]}

机构：

[1] Maastricht Univ, European Grad Sch Neurosci, Dept Psychiat & Neuropsychol, NL-6200 MD Maastricht, Netherlands

来源：

NEUROCHEMISTRY INTERNATIONAL | 2004年 / 45卷 / 06期

关键词：

nitric oxide; cGMP; acetylcholine; nitric oxide synthase; atropine; nicotine; central nervous system;

D O I：

10.1016/j.neuint.2004.03.010

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Already 30 years ago, it became apparent that there exists a relationship between acetylcholine and cGMP in the brain. Acetylcholine plays a role in a great number of processes in the brain, however, the role of cGMP in these processes is not known. A review of the data shows that, although the connection between NO-mediated cGMP synthesis and acetylcholine is firmly established, the complexities of the heterosynaptic pathways and the oligosynaptic structures involved preclude a clear definition of the role of cGMP in the functioning of acetylcholine presently. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：799 / 812

页数：14

共 206 条

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