CCK/dopamine interactions in Fawn-Hooded and Wistar-Kyoto rat brain

被引：14

作者：

Lodge, DJ ^{[1
]}

Short, JL ^{[1
]}

Mercer, LD ^{[1
]}

Beart, PM ^{[1
]}

Lawrence, AJ ^{[1
]}

机构：

[1] Monash Univ, Dept Pharmacol, Clayton, Vic 3168, Australia

来源：

PEPTIDES | 2000年 / 21卷 / 03期

基金：

英国医学研究理事会;

关键词：

CCK receptors; dopamine; nucleus accumbens; mesolimbic system; immunohistochemistry; alcohol-preferring rat;

D O I：

10.1016/S0196-9781(00)00159-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

The aim of this study was to compare the actions of CCK neuropeptides within the nucleus accumbens (N.Acc) of alcohol preferring (Fawn-Hooded, FH) and alcohol nonpreferring (Wistar-Kyoto, WKY) rats. CCK-8S (30-300 nM) facilitated the K+ stimulated release of [H-3]dopamine (DA) from N.Acc prisms in both rat strains, whereas CCK-4 (30 nM-1 mu M) caused a significant decrease of evoked [H-3]DA in the FH rat only. A scattered distribution of CCK-A and -B receptor immunopositive varicose fibers were visualized throughout the N.Acc of both rat strains along with a topographic distribution of CCK receptor positive cells throughout the ventral mesencephalon. (C) 2000 Elsevier Science Inc. All rights reserved.

引用

页码：379 / 386

页数：8

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