Brain-derived neurotrophic factor produces antidepressant effects in behavioral models of depression

被引：1316

作者：

Shirayama, Y ^{[1
]}

Chen, ACH ^{[1
]}

Nakagawa, S ^{[1
]}

Russell, DS ^{[1
]}

Duman, RS ^{[1
]}

机构：

[1] Yale Univ, Sch Med, Connecticut Mental Hlth Ctr, Abraham Ribicoff Res Facil,Div Mol Psychiat, New Haven, CT 06508 USA

来源：

JOURNAL OF NEUROSCIENCE | 2002年 / 22卷 / 08期

关键词：

neurotrophin-3; nerve growth factor; dentate gyrus; learned helplessness; forced swim test; hippocampus; MAP kinase;

D O I：

10.1523/JNEUROSCI.22-08-03251.2002

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Previous studies demonstrated that antidepressant treatment increases the expression of brain-derived neurotrophic factor (BDNF) in rat hippocampus. The present study was conducted to test the hypothesis that BDNF in the hippocampus produces an antidepressant effect in behavioral models of depression, the learned helplessness (LH) and forced swim test (FST) paradigms. A single bilateral infusion of BDNF into the dentate gyrus of hippocampus produced an antidepressant effect in both the LH and FST that was comparable in magnitude with repeated systemic administration of a chemical antidepressant. These effects were observed as early as 3 d after a single infusion of BDNF and lasted for at least 10 d. Similar effects were observed with neurotrophin-3 (NT-3) but not nerve growth factor. Infusions of BDNF and NT-3 did not influence locomotor activity or passive avoidance. The results provide further support for the hypothesis that BDNF contributes to the therapeutic action of antidepressant treatment.

引用

页码：3251 / 3261

页数：11

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