Acute and chronic nicotine exposure differentially facilitate the induction of LTP

被引：182

作者：

Fujii, S ^{[1
]}

Ji, ZX ^{[1
]}

Morita, N ^{[1
]}

Sumikawa, K ^{[1
]}

机构：

[1] Univ Calif Irvine, Dept Neurobiol & Behav, Irvine, CA 92697 USA

来源：

BRAIN RESEARCH | 1999年 / 846卷 / 01期

关键词：

nicotinic acetylcholine receptor; nicotine; long-term potentiation; hippocampus;

D O I：

10.1016/S0006-8993(99)01982-4

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We report here that acute and chronic nicotine exposure facilitated the induction of long-term potentiation (LTP), a leading candidate for a cellular mechanism underlying learning and memory, in the hippocampus. Furthermore, acute application of nicotine in chronic nicotine-treated hippocampus further facilitated the induction of LTP, suggesting that acute and chronic nicotine effects on LTP induction are mediated by different mechanisms. These findings not only provide evidence for chronic nicotine-induced synaptic changes in the hippocampus, but also an explanation of the cellular basis of nicotine-induced cognitive enhancement. (C) 1999 Elsevier Science B.V. All rights reserved.

引用

页码：137 / 143

页数：7

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