Genetics of asthma and inflammation: the status

被引：34

作者：

Moffatt, MF ^{[1
]}

Cookson, WOCM ^{[1
]}

机构：

[1] Wellcome Trust Ctr Human Genet, Oxford OX3 7BN, England

来源：

CURRENT OPINION IN IMMUNOLOGY | 1999年 / 11卷 / 06期

关键词：

D O I：

10.1016/S0952-7915(99)00024-2

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Genome-wide screens are consistently finding linkage between asthma-associated traits and specific chromosomal loci. Several loci coincide with linkages to other inflammatory diseases, suggesting the presence of common pathways in their pathogenesis. Candidate-gene studies have found an association between a CD14 polymorphism and IgE levels, suggesting a mechanism for the increased prevalence of allergic disease. A polymorphism in Fc epsilon RI-beta shows parent-of-origin effects when associated with severe infantile eczema, further illustrating the complexity of gene-environment effects on the developing immune system.

引用

页码：606 / 609

页数：4

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