Chemoenzymatic synthesis of the morphine skeleton via radical cyclization and a C-10-C-11 closure.

被引：40

作者：

Butora, G ^{[1
]}

Hudlicky, T ^{[1
]}

Fearnley, SP ^{[1
]}

Gum, AG ^{[1
]}

Stabile, MR ^{[1
]}

Abboud, K ^{[1
]}

机构：

[1] UNIV FLORIDA,DEPT CHEM,GAINESVILLE,FL 32611

来源：

TETRAHEDRON LETTERS | 1996年 / 37卷 / 45期

关键词：

D O I：

10.1016/0040-4039(96)01867-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A short synthesis of a morphinan skeleton has been accomplished. The key steps involve enzymatic dihydroxylation of beta-bromoethyl benzene, vinyl and aryl radical cyclizations, and Friedel-Crafts closure of an aziridinium ion or an acid-catalyzed closure of an aldehyde to form the C-10-C-11 bond. Copyright (C) 1996 Elsevier Science Ltd

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页码：8155 / 8158

页数：4

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