Relaxant effects of the essential oil of Ocimum gratissimum on isolated ileum of the guinea pig

被引：35

作者：

Madeira, SVF

Matos, FJA

Leal-Cardoso, JH

Criddle, DN

机构：

[1] Univ Estadual Ceara, Ctr Ciencias Saude, Dept Ciencias Fisiol, Lab Farmacol Canais Ionicos, BR-60740000 Fortaleza, Ceara, Brazil

[2] Univ Fed Ceara, Dept Quim Analit & Fis Quim, Lab Prod Nat, Fortaleza, Ceara, Brazil

来源：

JOURNAL OF ETHNOPHARMACOLOGY | 2002年 / 81卷 / 01期

关键词：

ocimum gratissimum; ileum; relaxation; labiatae;

D O I：

10.1016/S0378-8741(02)00049-1

中图分类号：

Q94 [植物学];

学科分类号：

071001 [植物学];

摘要：

The effects of the essential oil of Ocimum gratissimum L. (Labiatae) (EOOG) on guinea pig ileum were studied. EOOG (0.1-1000 mug/ml) reversibly and concentration-dependently relaxed the basal tone of the ileum and reversed the tonic contractions induced by 60 mM KCl and 10 muM acetylcholine, with IC50 values of 23.8 +/- 5.2, 18.6 +/- 4.0 and 70.0 +/- 4.6 mug/ml, respectively. Our results show that EOOG exerts relaxant effects on intestinal smooth muscle, consistent with the popular use of the plant to treat gastrointestinal disorders. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：1 / 4

页数：4

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