H2O2-induced apoptosis of thymocytes involves mobilization of divalent cations

被引:7
作者
Acharya, A [1 ]
机构
[1] Banaras Hindu Univ, Dept Zool, Fac Sci, Varanasi 221005, Uttar Pradesh, India
关键词
hydrogen peroxide; calcium ions (Ca+2); apoptosis; thymocyte;
D O I
10.1177/039463200201500305
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
More than 90% of thymocytes undergo apoptosis while undergoing differentiation in the thymus. Although several factors act in concert to induce thymocyte apoptosis, it remains speculative if reactive oxygen intermediates produced by thymic macrophages may play a role in this process. The present investigation was carried out to determine if H2O2 is capable of inducing apoptosis of thymocytes in vitro. It was observed that H2O2 could induce apoptosis of thymocytes ill vitro in a dose and time dependent manner. It was further found that H2O2-induced thymocyte apoptosis was dependent on the mobilization of divalent cations. The result of this study will help further in the understanding of the mechanism of H2O2-induced apoptosis.
引用
收藏
页码:195 / 200
页数:6
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