Acyl Dipeptides as reversible caspase inhibitors. Part 1: Initial lead optimization

被引：34

作者：

Linton, SD ^{[1
]}

Karanewsky, DS ^{[1
]}

Ternansky, RJ ^{[1
]}

Wu, JC ^{[1
]}

Pham, B ^{[1
]}

Kodandapani, L ^{[1
]}

Smidt, R ^{[1
]}

Diaz, JL ^{[1
]}

Fritz, LC ^{[1
]}

Tomaselli, KJ ^{[1
]}

机构：

[1] Idun Pharmaceut Inc, San Diego, CA 92121 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2002年 / 12卷 / 20期

关键词：

D O I：

10.1016/S0960-894X(02)00629-7

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Parallel synthesis was used to explore the SAR of a peptidomimetic caspase inhibitor. The most potent compound had nanomolar activity against caspases 1, 3, 6, 7, and 8. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：2969 / 2971

页数：3

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