Perspectives and Challenges in Tissue Engineering and Regenerative Medicine

被引:151
作者
Langer, Robert [1 ]
机构
[1] MIT, Dept Chem Engn, Cambridge, MA 02139 USA
关键词
ENDOCRINE PANCREAS; SKIN;
D O I
10.1002/adma.200902589
中图分类号
O6 [化学];
学科分类号
070301 [无机化学];
摘要
The various perspectives and challenges in tissue engineering and regenerative medicines are discussed. Several scientists had also done work where they used two dimensional scaffolds composed of natural polymers such as collagen as scaffolds for tissue regenerative devices. A new system with a highly porous structure to meet the needs of mass transfer of oxygen and nutrients for a large number of cells is also developed. There are many examples of new polymer scaffolds which are being developed. It have been reviewed in various papers but some of these challenges include creating the right kind of materials for cell transplantation, developing methods of tissue and cell preservation for long times in storage, inducing appropriate blood vessel and nerve growth for the tissues, and preventing tissue and cell rejection.
引用
收藏
页码:3235 / 3236
页数:2
相关论文
共 13 条
[1]
LIVING TISSUE FORMED INVITRO AND ACCEPTED AS SKIN-EQUIVALENT TISSUE OF FULL THICKNESS [J].
BELL, E ;
EHRLICH, HP ;
BUTTLE, DJ ;
NAKATSUJI, T .
SCIENCE, 1981, 211 (4486) :1052-1054
[2]
BISCEGLIE V., 1933, ZEITSCHR KREBSFORSCH, V40, P122
[3]
SUCCESSFUL USE OF A PHYSIOLOGICALLY ACCEPTABLE ARTIFICIAL SKIN IN THE TREATMENT OF EXTENSIVE BURN INJURY [J].
BURKE, JF ;
YANNAS, IV ;
QUINBY, WC ;
BONDOC, CC ;
JUNG, WK .
ANNALS OF SURGERY, 1981, 194 (04) :413-428
[4]
BETA CELL-CULTURE ON SYNTHETIC CAPILLARIES - ARTIFICIAL ENDOCRINE PANCREAS [J].
CHICK, WL ;
LIKE, AA ;
LAURIS, V .
SCIENCE, 1975, 187 (4179) :847-849
[5]
PROGRESS IN TISSUE ENGINEERING [J].
Khademhosseini, Ali ;
Vacanti, Joseph P. ;
Langer, Robert .
SCIENTIFIC AMERICAN, 2009, 300 (05) :64-+
[6]
Designing materials for biology and medicine [J].
Langer, R ;
Tirrell, DA .
NATURE, 2004, 428 (6982) :487-492
[7]
TISSUE ENGINEERING [J].
LANGER, R ;
VACANTI, JP .
SCIENCE, 1993, 260 (5110) :920-926
[8]
Tissue engineering: The challenges ahead [J].
Langer, RS ;
Vacanti, JP .
SCIENTIFIC AMERICAN, 1999, 280 (04) :86-89
[9]
MICROENCAPSULATED ISLETS AS BIOARTIFICIAL ENDOCRINE PANCREAS [J].
LIM, F ;
SUN, AM .
SCIENCE, 1980, 210 (4472) :908-910
[10]
Generation of germline-competent induced pluripotent stem cells [J].
Okita, Keisuke ;
Ichisaka, Tomoko ;
Yamanaka, Shinya .
NATURE, 2007, 448 (7151) :313-U1