CTLA-4-Ig regulates tryptophan catabolism in vivo

被引：944

作者：

Grohmann, U ^{[1
]}

Orabona, C

Fallarino, F

Vacca, C

Calcinaro, F

Falorni, A

Candeloro, P

Belladonna, ML

Bianchi, R

Fioretti, MC

Puccetti, P

机构：

[1] Univ Perugia, Dept Expt Med, I-06126 Perugia, Italy

[2] Univ Perugia, Dept Internal Med, I-06126 Perugia, Italy

来源：

NATURE IMMUNOLOGY | 2002年 / 3卷 / 11期

关键词：

D O I：

10.1038/ni846

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) plays a critical role in peripheral tolerance. However, regulatory pathways initiated by the interactions of CTLA-4 with B7 counterligands expressed on antigen-presenting cells are not completely understood. We show here that long-term survival of pancreatic islet allografts induced by the soluble fusion protein CTLA-4-immunoglobulin (CTLA-4-Ig) is contingent upon effective tryptophan catabolism in the host. In vitro, we show that CTLA-4-Ig regulates cytokine-dependent tryptophan catabolism in B37-expressing dendritic cells. These data suggest that modulation of tryptophan catabolism is a means by which CTLA-4 functions in vivo and that CTLA-4 acts as a ligand for B7 receptor molecules that transduce intracellular signals.

引用

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页码：1097 / 1101

页数：5

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