ω-6 polyunsaturated fatty acid γ-linolenic acid (18:3n-6) is a selective estrogen-response modulator in human breast cancer cells:: γ-linolenic acid antagonizes estrogen receptor-dependent transcriptional activity, transcriptionally represses estrogen receptor expression and synergistically enhances tamoxifen and ICI 182,780 (Faslodex) efficacy in human breast cancer cells

被引:22
作者
Menendez, JA
Colomer, R
Lupu, R
机构
[1] Evanston NW Healthcare Res Inst, Dept Med, Evanston, IL 60201 USA
[2] Northwestern Univ, Feinberg Sch Med, Chicago, IL 60611 USA
[3] Hosp Univ Dr Josep Trueta, Inst Catala Oncol, Girona, Spain
关键词
D O I
10.1002/ijc.20096
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
引用
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页码:949 / 954
页数:6
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