Nrk:: a murine X-linked NIK (Nck-interacting kinase)-related kinase gene expressed in skeletal muscle

被引：38

作者：

Kanai-Azuma, M

Kanai, Y

Okamoto, M

Hayashi, Y

Yonekawa, H

Yazaki, K

机构：

[1] Univ Tokyo, Dept Vet Anat, Bunkyo Ku, Tokyo 113, Japan

[2] Tokyo Metropolitan Inst Med Sci, Dept Ultrastruct Res, Bunkyo Ku, Tokyo 113, Japan

[3] Tokyo Metropolitan Inst Med Sci, Dept Lab Anim Sci, Bunkyo Ku, Tokyo 113, Japan

来源：

MECHANISMS OF DEVELOPMENT | 1999年 / 89卷 / 1-2期

关键词：

Nrk; Ste20; NIK; GCK; KHS; KPK1; kinase; skeletal muscle; myogenesis; myogenin;

D O I：

10.1016/S0925-4773(99)00193-8

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We report the cloning and expression pattern of a novel Ste20-type kinase gene, NIK-related kinase (Nrk), located on the mouse X chromosome, The full-length Nrk cDNA encodes a 1455-amino-acid polypeptide characterized by a N-terminal Ste20-type catalytic domain and a C-terminal regulatory domain characteristic of the group I GCK subfamily. The overall structure of the NRK protein is closely related to that of Nck-interacting kinase (Nik). In situ hybridization revealed that Nrk was predominantly expressed in skeletal muscle during mouse embryogenesis. Nrk gene expression was detected in the myotome at 10.5 dpc and, thereafter, was observed in developing skeletal musculature from 11.5 to 13.5 dpc. However, expression in skeletal muscle was not observed in adults. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：155 / 159

页数：5

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