Whole-Brain Perfusion CT Performed with a Prototype 256-Detector Row CT System: Initial Experience

被引：56

作者：

Murayama, Kazuhiro ^{[1
]}

Katada, Kazuhiro ^{[1
]}

Nakane, Masato ^{[4
]}

Toyama, Hiroshi ^{[1
]}

Anno, Hirofumi ^{[2
]}

Hayakawa, Motoharu ^{[3
]}

Ruiz, Diego San Millan ^{[5
]}

Murphy, Kieran J. ^{[5
]}

机构：

[1] Fujita Hlth Univ, Dept Radiol, Aichi 4701192, Japan

[2] Fujita Hlth Univ, Fac Radiol Technol, Sch Hlth Sci, Aichi 4701192, Japan

[3] Fujita Hlth Univ, Dept Neurosurg, Aichi 4701192, Japan

[4] Nagoya Cent Hosp, Dept Radiol, Nagoya, Aichi, Japan

[5] Johns Hopkins Med Inst, Dept Radiol, Div Intervent Neuroradiol, Baltimore, MD 21205 USA

来源：

RADIOLOGY | 2009年 / 250卷 / 01期

关键词：

CEREBRAL-BLOOD-FLOW; ACUTE STROKE PATIENTS; COMPUTED-TOMOGRAPHY; ISCHEMIC-STROKE; VALIDATION; DIFFUSION; REPRODUCIBILITY; IODINE-123-IMP; PARAMETERS; PROGNOSIS;

D O I：

10.1148/radiol.2501071809

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Purpose: To preliminarily evaluate the feasibility and potential diagnostic utility of whole-brain perfusion computed tomography (CT) performed with a prototype 256-detector row CT system over an extended range covering the entire brain to assess ischemic cerebrovascular disease. Materials and Methods: Institutional review board approval and informed consent were obtained. Eleven cases in 10 subjects (six men, four women; mean age, 64.3 years) with intra- or extracranial stenosis were retrospectively evaluated with whole-brain perfusion CT. Three readers independently evaluated perfusion CT data. The diagnostic performance of perfusion CT was visually evaluated with a three-point scale used to assess three factors. Differences between four axial perfusion CT images obtained at the basal ganglia level (hereafter, four-section images) and whole-brain perfusion CT images were assessed with the paired t test. In four subjects, the interval between perfusion CT and single photon emission computed tomography (SPECT) was 1-17 days (mean, 10.3 days). Correlation between perfusion CT findings and SPECT findings was assessed with the Spearman correlation coefficient. Results: Three-dimensional perfusion CT images and axial, coronal, and sagittal whole-brain perfusion CT images were displayed, and the extent of ischemia was assessed. Mean visual evaluation scores were significantly higher for whole-brain images than for four-section images (4.27 +/- 0.76 [standard deviation] vs 2.55 +/- 0.87). The cerebral blood flow ratios of the ischemic lesions relative to normal regions scanned with perfusion CT (x) and SPECT (y) showed a significant positive correlation (R-2 = 0.76, y = 0.44x + 0.37, P <.001). Conclusion: Perfusion CT performed with a 256-detector row CT system can be used to assess the entire brain with administration of one contrast medium bolus. Thus, ischemic regions can be identified with one examination, which has the potential to improve diagnostic utility. (C) RSNA, 2009

引用

页码：202 / 211

页数：10

共 33 条

[1]

Baron J C, 1981, Trans Am Neurol Assoc, V105, P459

[2] NON-INVASIVE TOMOGRAPHIC STUDY OF CEREBRAL BLOOD-FLOW AND OXYGEN-METABOLISM INVIVO - POTENTIALS, LIMITATIONS, AND CLINICAL-APPLICATIONS IN CEREBRAL ISCHEMIC DISORDERS [J].