Ergothioneine treatment protects neurons against N-methyl-D-aspartate excitotoxicity in an in vivo rat retinal model

被引：69

作者：

Moncaster, JA ^{[1
]}

Walsh, DT ^{[1
]}

Gentleman, SM ^{[1
]}

Jen, LS ^{[1
]}

Aruoma, OI ^{[1
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Charing Cross Hosp, Dept Neuroinflammat, Div Neurosci & Psychol Med,Fac Med, London W6 8RF, England

来源：

NEUROSCIENCE LETTERS | 2002年 / 328卷 / 01期

基金：

英国惠康基金; 英国医学研究理事会;

关键词：

ergothioneine; N-methyl-D-aspartate; retinal ganglion cells; antioxidants; free radicals; neurodegeneration;

D O I：

10.1016/S0304-3940(02)00427-5

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Injection of the glutamate agonist N-methyl-D-aspartate into the vitreous body of the rat eye resulted in a number of morphological changes in the retina. Most apparent was a dramatic reduction in the density and sizes of neurons accompanied by a decrease in amyloid precursor protein and glial fibrillary acidic protein immunoreactivity. Cell counts revealed that 81% of ganglion cells and 43% of non-ganglion cells were lost as a result of the treatment. However, in animals treated with the antioxidant ergothioneine, these figures dropped to 44 and 31%, respectively. Thus, ergothioneine appears to be neuroprotective in this system and the data suggest that antioxidants may provide a useful means of modulating glutamate-based toxicity. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：55 / 59

页数：5

共 20 条

[1] THE ANTIOXIDANT ACTION OF ERGOTHIONEINE [J].