Aspirin and clopidogrel: efficacy and resistance in diabetes mellitus

被引：53

作者：

Angiolillo, Dominick J. ^{[1
]}

Suryadevara, Siva ^{[1
]}

机构：

[1] Univ Florida, Coll Med Jacksonville, Dept Cardiol, Jacksonville, FL 32209 USA

来源：

BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM | 2009年 / 23卷 / 03期

关键词：

platelet; aspirin; clopidogrel; diabetes mellitus; resistance; CORONARY-ARTERY-DISEASE; LOW-DOSE ASPIRIN; INDUCED PLATELET ACTIVATION; DUAL ANTIPLATELET THERAPY; SHORT-TERM HYPERGLYCEMIA; LOW-DENSITY-LIPOPROTEIN; MYOCARDIAL-INFARCTION; IN-VIVO; THROMBOXANE BIOSYNTHESIS; CLINICAL-PRACTICE;

D O I：

10.1016/j.beem.2008.12.001

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Diabetes mellitus patients are characterized by enhanced platelet reactivity which exposes them to an increased risk of atherothrombotic events in the setting of acute coronary syndromes or percutaneous coronary interventions. Although aspirin and clopidogrel, used either solely or in combination, are associated with improved clinical Outcomes in high-risk patients, diabetics patients treated with antiplatelet agents remain at higher risk of recurrent ischemic events. Recent laboratory findings Suggest that this observation may be related to a reduced responsiveness or 'resistance' to these agents. In this chapter the efficacy Of Currently available oral antiplatelet agents in preventing ischemic events is reviewed. In addition, the antiplatelet 'resistance' phenomenon in the diabetic Population and its impact on clinical Outcomes is summarized. Finally, future developments in the field directed towards individualized treatment strategies and novel antiplatelet agents are examined. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：375 / 388

页数：14

共 95 条

[1] COLLABORATIVE OVERVIEW OF RANDOMIZED TRIALS OF ANTIPLATELET THERAPY .1. PREVENTION OF DEATH, MYOCARDIAL-INFARCTION, AND STROKE BY PROLONGED ANTIPLATELET THERAPY IN VARIOUS CATEGORIES OF PATIENTS [J].

ALTMAN, R ;

CARRERAS, L ;

DIAZ, R ;

FIGUEROA, E ;

PAOLASSO, E ;

PARODI, JC ;

CADE, JF ;

DONNAN, G ;

EADIE, MJ ;

GAVAGHAN, TP ;

OSULLIVAN, EF ;

PARKIN, D ;

RENNY, JTG ;

SILAGY, C ;

VINAZZER, H ;

ZEKERT, F ;

ADRIAENSEN, H ;

BERTRANDHARDY, JM ;

BRAN, M ;

DAVID, JL ;

DRICOT, J ;

LAVENNEPARDONGE, E ;

LIMET, R ;

LOWENTHAL, A ;

MORIAU, M ;

SCHAPIRA, S ;

SMETS, P ;

SYMOENS, J ;

VERHAEGHE, R ;

VERSTRAETE, M ;

ATALLAH, A ;

BARNETT, H ;

BATISTA, R ;

BLAKELY, J ;

CAIRNS, JA ;

COTE, R ;

CROUCH, J ;

EVANS, G ;

FINDLAY, JM ;

GENT, M ;

LANGLOIS, Y ;

LECLERC, J ;

NORRIS, J ;

PINEO, GF ;

POWERS, PJ ;

ROBERTS, R ;

SCHWARTZ, L ;

SICURELLA, J ;

TAYLOR, W ;

THEROUX, P .

BMJ-BRITISH MEDICAL JOURNAL, 1994, 308 (6921) :81-100

[2] ACC/AHA 2007 guide lines for the management of patients with unstable Angina/Non-ST-Elevation myocardial infraction - Executive summary [J].

Anderson, Jeffrey L. ;

Adams, Cynthia D. ;

Antman, Elliott M. ;

Bridges, Charles R. ;

Califf, Robert M. ;

Casey, Donald E., Jr. ;

Chavey, William E., II ;

Fesmire, Francis M. ;

Hochman, Judith S. ;

Levin, Thomas N. ;

Lincoff, A. Michael ;

Peterson, Eric D. ;

Theroux, Pierre ;

Wenger, Nanette Kass ;

Wright, R. Scott ;

Smith, Sidney C., Jr. ;

Jacobs, Alice K. ;

Adams, Cynthia D. ;

Riegel, Barbara .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2007, 50 (07) :652-726

[3] Platelet function profiles in patients with type 2 diabetes and coronary artery disease on combined aspirin and clopidogrel treatment [J].

Angiolillo, DJ ;

Fernandez-Ortiz, A ;

Bernardo, E ;

Ramírez, C ;

Sabaté, M ;

Jimenez-Quevedo, P ;

Hernández, R ;

Moreno, R ;

Escaned, J ;

Alfonso, F ;

Bañuelos, C ;

Costa, MA ;

Bass, TA ;

Macaya, C .

DIABETES, 2005, 54 (08) :2430-2435

[4] A randomized study assessing the impact of cilostazol on platelet function profiles in patients with diabetes mellitus and coronary artery disease on dual antiplatelet therapy: results of the OPTIMUS-2 study [J].

Angiolillo, Dominick J. ;

Capranzano, Piera ;

Goto, Shinya ;

Aslam, Mohammed ;

Desai, Bhaloo ;

Charlton, Ronald K. ;

Suzuki, Yoshie ;

Box, Lyndon C. ;

Shoemaker, Steven B. ;

Zenni, Martin M. ;

Guzman, Luis A. ;

Bass, Theodore A. .

EUROPEAN HEART JOURNAL, 2008, 29 (18) :2202-2211

[5] Current antiplatelet therapies: Benefits and limitations [J].

Angiolillo, Dominick J. ;

Guzman, Luis A. ;

Bass, Theodore A. .

AMERICAN HEART JOURNAL, 2008, 156 (02) :S3-S9

[6] Clinical overview of promising nonthienopyridine antiplatelet agents [J].

Angiolillo, Dominick J. ;

Guzman, Luis A. .

AMERICAN HEART JOURNAL, 2008, 156 (02) :S23-S28

[7] Clinical profile of prasugrel, a novel thienopyridine [J].

Angiolillo, Dominick J. ;

Bates, Eric R. ;

Bass, Theodore A. .

AMERICAN HEART JOURNAL, 2008, 156 (02) :S16-S22

[8] ADP receptor antagonism - What's in the pipeline? [J].

Angiolillo, Dominick J. .

AMERICAN JOURNAL OF CARDIOVASCULAR DRUGS, 2007, 7 (06) :423-432

[9] Impact of platelet reactivity on cardiovascular outcomes in patients with type 2 diabetes mellitus and coronary artery disease [J].

Angiolillo, Dominick J. ;

Bernardo, Esther ;

Sabate, Manel ;

Jimenez-Quevedo, Pilar ;

Costa, Marco A. ;

Palazuelos, Jorge ;

Hernandez-Antolin, Rosana ;

Moreno, Raul ;

Escaned, Javier ;

Alfonso, Fernando ;

Banuelos, Camino ;

Guzman, Luis A. ;

Bass, Theodore A. ;

Macaya, Carlos ;

Fernandez-Ortiz, Antonio .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2007, 50 (16) :1541-1547

[10] Randomized comparison of a high clopidogrel maintenance dose in patients with diabetes mellitus and coronary artery disease - Results of the Optimizing antiPlatelet Therapy In diabetes MellitUS (OPTIMUS) study [J].

Angiolillo, Dominick J. ;

Shoemaker, Steven B. ;

Desai, Bhaloo ;

Yuan, Hang ;

Charlton, Ronald K. ;

Bernardo, Esther ;

Zenni, Martin M. ;

Guzman, Luis A. ;

Bass, Theodore A. ;

Costa, Marco A. .

CIRCULATION, 2007, 115 (06) :708-716

← 1 2 3 4 5 6 7 8 9 10 →