Prevalence of smell loss in Parkinson's disease - A multicenter study

被引：300

作者：

Haehner, A. ^{[1
,5
]}

Boesveldt, S. ^{[2
]}

Berendse, H. W. ^{[2
]}

Mackay-Sim, A. ^{[3
]}

Fleischmann, J. ^{[1
,3
]}

Silburn, P. A. ^{[3
,4
]}

Johnston, A. N. ^{[3
]}

Mellick, G. D. ^{[3
]}

Herting, B.

Reichmann, H. ^{[5
]}

Hummel, T. ^{[1
]}

机构：

[1] Univ Dresden, Dept Otorhinolaryngol, Sch Med, D-01307 Dresden, Germany

[2] Vrije Univ Amsterdam, Dept Neurol, Med Ctr, Amsterdam, Netherlands

[3] Griffith Univ, Eskitis Inst Cell & Mol Therapies, Brisbane, Qld 4111, Australia

[4] Univ Queensland, Sch Med, Brisbane, Qld, Australia

[5] Univ Dresden, Dept Neurol, Sch Med, D-01307 Dresden, Germany

来源：

PARKINSONISM & RELATED DISORDERS | 2009年 / 15卷 / 07期

关键词：

Smell; Olfaction; Parkinson's disease; Neurodegenerative disorder; OLFACTORY FUNCTION; ODOR DISCRIMINATION; IDENTIFICATION; IMPAIRMENT; PERFORMANCE; DYSFUNCTION; DIAGNOSIS; DISORDER; HYPOSMIA; CRITERIA;

D O I：

10.1016/j.parkreldis.2008.12.005

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Previous data on the prevalence of olfactory dysfunction in Parkinson's disease (PD) range from 45% to 90%. The present Multicenter study aimed to provide data on the prevalence of smell loss in a large sample of PD patients from three independent populations. Olfactory sensitivity was tested in 400 patients from Australia, Germany, and The Netherlands by means of a psychophysical olfactory test, the "Sniffin' Sticks", which is comprised of 3 subtests of olfactory function. Out of the total number of patients 45.0% presented as functionally anosmic, 51.7% were hyposmic, whereas only 3.3% were normosmic. This indicates that 96.7% of PD patients present with significant olfactory loss when compared to young normosmic subjects. This figure falls to 74.5%, however, when adjusted to age-related norms. Thus, olfactory dysfunction should be considered as a reliable marker of the disease. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：490 / 494

页数：5

共 29 条

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