ON cone bipolar cells in rat express the metabotropic receptor mGluR6

被引：106

作者：

Vardi, N

Morigiwa, K

机构：

[1] Department of Neuroscience, University of Pennsylvania, Philadelphia

[2] Department of Neuroscience, University of Pennsylvania, Philadelphia

[3] Department of Physiology, Osaka University, Medical School, Suita 565

来源：

VISUAL NEUROSCIENCE | 1997年 / 14卷 / 04期

关键词：

L-AP4; rod bipolar; G-protein;

D O I：

10.1017/S0952523800012736

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The rod bipolar cell and about five types of ON cone bipolar cells depolarize to light by employing a sign-reversing metabotropic glutamate receptor. Glutamate responses are similar in both rod bipolar and cone bipolar cells, but the receptor mediating this response (mGluR6) was so far demonstrated only in rod bipolar cells. To test if ON cone bipolar cells also express mGluR6, we immunoreacted rat retina with an antibody specific for mGluR6, and studied the staining from serial ultrathin sections. We demonstrate that mGluR6 is indeed expressed in the dendritic tips of cone bipolar cells, the majority of which receive a ribbon synapse, and thus probably are ON cone bipolar cells. We further show that half of the dendritic tips contacting the cones stain for mGluR6, thus implying that all ON cone bipolar cell types express mGluR6.

引用

页码：789 / 794

页数：6

共 44 条

[1] EXPRESSION OF MESSENGER-RNAS OF L-AP4-SENSITIVE METABOTROPIC GLUTAMATE RECEPTORS (MGLUR4, MGLUR6, MGLUR7) IN THE RAT RETINA [J].