Establishing outcome measures in early knee osteoarthritis

被引：125

作者：

Emery, Carolyn A. ^{[1
,2
,3
]}

Whittaker, Jackie L. ^{[4
]}

Mahmoudian, Armaghan ^{[5
]}

Lohmander, L. Stefan ^{[6
]}

Roos, Ewa M. ^{[7
]}

Bennell, Kim L. ^{[8
]}

Toomey, Clodagh M. ^{[1
,2
,3
]}

Reimer, Raylene A. ^{[9
,10
]}

Thompson, Dylan ^{[11
]}

Ronsky, Janet L. ^{[3
,12
]}

Kuntze, Gregor ^{[1
,2
,3
]}

Lloyd, David G. ^{[13
]}

Andriacchi, Thomas ^{[14
,15
,16
]}

Englund, Martin ^{[17
]}

Kraus, Virginia B. ^{[18
,19
]}

Losina, Elena ^{[20
,21
]}

Bierma-Zeinstra, Sita ^{[22
]}

Runhaar, Jos ^{[23
]}

Peat, George ^{[24
]}

Luyten, Frank P. ^{[5
]}

Snyder-Mackler, Lynn ^{[25
,26
]}

Risberg, May Arna ^{[27
,28
]}

Mobasheri, Ali ^{[29
,30
]}

Guermazi, Ali ^{[31
]}

Hunter, David J. ^{[32
,33
]}

Arden, Nigel K. ^{[34
]}

机构：

[1] Univ Calgary, Sport Injury Prevent Res Ctr, Fac Kinesiol, Calgary, AB, Canada

[2] Univ Calgary, Alberta Childrens Hosp Res Inst, Calgary, AB, Canada

[3] Univ Calgary, Cumming Sch Med, McCaig Inst Bone & Joint Hlth, Calgary, AB, Canada

[4] Univ Alberta, Fac Rehabil Med, Dept Phys Therapy, Edmonton, AB, Canada

[5] Katholieke Univ Leuven, Skeletal Biol & Engn Res Ctr, Div Rheumatol, Univ Hosp, Leuven, Belgium

[6] Lund Univ, Dept Clin Sci Lund, Orthopaed, Lund, Sweden

[7] Univ Southern Denmark, Dept Sports & Clin Biomech, Odense, Denmark

[8] Univ Melbourne, Ctr Hlth Exercise & Sports Med, Melbourne, Vic, Australia

[9] Univ Calgary, Fac Kinesiol, Calgary, AB, Canada

[10] Univ Calgary, Dept Biochem & Mol Biol, Calgary, AB, Canada

[11] Univ Bath, Dept Hlth, Bath, Avon, England

[12] Univ Calgary, Schulich Sch Engn, Fac Kinesiol, Calgary, AB, Canada

[13] Griffith Univ, Gold Coast Orthopaed Res Engn & Educ GCORE, Menzies Hlth Inst Queensland, Gold Coast, Qld, Australia

[14] Stanford Univ, Dept Mech Engn, Stanford, CA 94305 USA

[15] Stanford Univ, Dept Orthoped Surg, Stanford, CA 94305 USA

[16] Palo Alto Vet Affairs Hlth Care Syst, Palo Alto, CA USA

[17] Lund Univ, Dept Clin Sci Lund, Clin Epidemiol Unit, Orthopaed, Lund, Sweden

[18] Duke Univ, Sch Med, Duke Mol Physiol Inst, Durham, NC USA

[19] Duke Univ, Sch Med, Dept Med, Div Rheumatol, Durham, NC 27706 USA

[20] Harvard Med Sch, Orthopaed & Arthrit Ctr Outcomes Res, Brigham & Womens Hosp, Boston, MA 02115 USA

[21] Boston Univ, Sch Publ Hlth, Boston, MA USA

[22] Erasmus MC, Dept Orthopaed, Univ Med Ctr Rotterdam, Rotterdam, Netherlands

[23] Erasmus MC, Dept Gen Practice, Univ Med Ctr Rotterdam, Rotterdam, Netherlands

[24] Keele Univ, Res Inst Primary Care & Hlth Sci, Keele, Staffs, England

[25] Univ Delaware, STAR Hlth, Dept Phys Therapy, Newark, DE USA

[26] Univ Delaware, STAR Hlth, Dept Biomed Engn, Newark, DE USA

[27] Oslo Univ Hosp, Norwegian Res Ctr Act Rehabil, Dept Sports Med, Norwegian Sch Sport Sci, Oslo, Norway

[28] Oslo Univ Hosp, Div Orthopaed Surg, Oslo, Norway

[29] State Res Inst Ctr Innovat Med, Dept Regenerat Med, Vilnius, Lithuania

[30] Queens Med Ctr, Nottingham, England

[31] Boston Univ, Sch Med, Boston, MA 02118 USA

[32] Univ Sydney, Inst Bone & Joint Res, Kolling Inst, Sydney, NSW, Australia

[33] Royal North Shore Hosp, Rheumatol Dept, Sydney, NSW, Australia

[34] Univ Oxford, Oxford, England

来源：

NATURE REVIEWS RHEUMATOLOGY | 2019年 / 15卷 / 07期

关键词：

ASSESS PHYSICAL FUNCTION; EXCURSION BALANCE TEST; OLIGOMERIC MATRIX PROTEIN; CRUCIATE LIGAMENT INJURY; LOWER-EXTREMITY INJURY; WHOLE JOINT ASSESSMENT; CLINICAL-TRIALS; OLDER-ADULTS; SCORE KOOS; BODY-COMPOSITION;

D O I：

10.1038/s41584-019-0237-3

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

The classification and monitoring of individuals with early knee osteoarthritis (OA) are important considerations for the design and evaluation of therapeutic interventions and require the identification of appropriate outcome measures. Potential outcome domains to assess for early OA include patient-reported outcomes (such as pain, function and quality of life), features of clinical examination (such as joint line tenderness and crepitus), objective measures of physical function, levels of physical activity, features of imaging modalities (such as of magnetic resonance imaging) and biochemical markers in body fluid. Patient characteristics such as adiposity and biomechanics of the knee could also have relevance to the assessment of early OA. Importantly, research is needed to enable the selection of outcome measures that are feasible, reliable and validated in individuals at risk of knee OA or with early knee OA. In this Perspectives article, potential outcome measures for early symptomatic knee OA are discussed, including those measures that could be of use in clinical practice and/or the research setting.

引用

页码：438 / 448

页数：11

共 187 条

[1]

Validity and Reliability of the 20 Meter Shuttle Run Test in Military Personnel [J].