Improved regional function after autologous bone marrow-derived stem cell transfer in patients with acute myocardial infarction: a randomized, double-blind strain rate imaging study

被引：76

作者：

Herbots, Lieven ^{[1
]}

D'hooge, Jan ^{[1
]}

Eroglu, Elif ^{[1
]}

Thijs, Daisy ^{[1
]}

Ganame, Javier ^{[1
]}

Claus, Piet ^{[1
]}

Dubois, Christophe ^{[1
]}

Theunissen, Koen ^{[2
]}

Bogaert, Jan ^{[3
]}

Dens, Joseph ^{[1
]}

Kalantzi, Maria ^{[3
]}

Dymarkowski, Steven ^{[3
]}

Bijnens, Bart ^{[1
]}

Belmans, Ann ^{[1
]}

Boogaerts, Marc ^{[2
,4
]}

Sutherland, George ^{[1
]}

Van de Werf, Frans ^{[1
]}

Rademakers, Frank ^{[1
]}

Janssens, Stefan ^{[1
,5
]}

机构：

[1] Univ Louvain, Univ Hosp Gasthuisberg, Dept Cardiol, B-3000 Leuven, Belgium

[2] Univ Louvain, Univ Hosp Gasthuisberg, Dept Haematol, B-3000 Leuven, Belgium

[3] Univ Louvain, Univ Hosp Gasthuisberg, Dept Radiol, B-3000 Leuven, Belgium

[4] Univ Louvain, Univ Hosp Gasthuisberg, SCIL, B-3000 Leuven, Belgium

[5] Univ Louvain, Univ Hosp Gasthuisberg, Ctr Transgene Technol & Gene Therapy, B-3000 Leuven, Belgium

来源：

EUROPEAN HEART JOURNAL | 2009年 / 30卷 / 06期

关键词：

Stem cell therapy; Regional myocardial function; Strain rate imaging; Acute myocardial infarction; LEFT-VENTRICULAR FUNCTION; ISCHEMIC-HEART FAILURE; PROGENITOR CELLS; SEGMENT ELEVATION; INJECTION; TRIAL; ECHOCARDIOGRAPHY; TRANSPLANTATION; REGENERATION; DEFORMATION;

D O I：

10.1093/eurheartj/ehn532

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

To investigate whether intracoronary transfer of bone marrow progenitor cells (BMPCs) early after reperfusion of an acute myocardial infarction improves regional myocardial function in a randomized double-blind, placebo-controlled strain rate imaging study. Regional myocardial deformation was measured using velocity-derived strain rate imaging in 67 STEMI patients randomized 1:1 to intracoronary infusion of BMPC (n = 33) or placebo (n = 34). Myocardial segments were grouped into infarct (n = 232), border (n = 250), and remote (n = 526) based on MRI-delayed enhancement and the perfusion territory of the infarct-related vessel. Four months after revascularization and progenitor cell/placebo transfer, regional myocardial deformation (rate) improved significantly more in the infarct segments of BMPC patients (treatment effect on end-systolic strain: -3.7 +/- 1.0%, P = 0.0003; peak-systolic strain rate: -0.20 +/- 0.07 s(-1), P = 0.0035). These findings were confirmed by a significantly greater improvement of longitudinal mitral valve ring displacement in the infarct walls of BMPC patients (treatment effect: 0.93 mm, P = 0.034). Intracoronary infusion of BMPC early after reperfusion of a STEMI improves recuperation of regional myocardial function at 4 months' follow-up. Quantitative assessment of regional systolic function might be more sensitive than global LV ejection fraction for the evaluation of BMPC therapy after STEMI.

引用

页码：662 / 670

页数：9

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