Lipoic acid reduces inflammation in a mouse focal cortical experimental autoimmune encephalomyelitis model

被引：21

作者：

Chaudhary, Priya ^{[1
]}

Marracci, Gail ^{[1
,2
]}

Galipeau, Danielle ^{[1
]}

Pocius, Edvinas ^{[1
]}

Morris, Brooke ^{[1
]}

Bourdette, Dennis ^{[1
,2
,3
]}

机构：

[1] Oregon Hlth & Sci Univ, Dept Neurol, Portland, OR 97239 USA

[2] Dept Vet Affairs Med Ctr, Res, Portland, OR 97239 USA

[3] Dept Vet Affairs Med Ctr, Neurol Serv, Portland, OR 97239 USA

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2015年 / 289卷

关键词：

Cortical lesions; Focal EAE; Multiple sclerosis; Inflammation; Immunofluorescence; CENTRAL-NERVOUS-SYSTEM; T-CELL MIGRATION; MULTIPLE-SCLEROSIS; SPINAL-CORD; ANIMAL-MODEL; LESIONS; ALPHA; DEMYELINATION; EXPRESSION; INJECTION;

D O I：

10.1016/j.jneuroim.2015.10.011

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

Cortical lesions are a crucial part of MS pathology and it is critical to determine that new MS therapies have the ability to alter cortical inflammatory lesions given the differences between white and gray matter lesions. We tested lipoic acid (LA) in a mouse focal cortical EAE model. Brain sections were stained with antibodies against CD4, CD11 b and galectin-3. Compared with vehicle, treatment with LA significantly decreased CD4+ and galectin-3 + immune cells in the brain. LA treated mice had fewer galectin-3 + cells with no projections indicating decrease in the number of infiltrating monocytes. LA significantly reduces inflammation in a focal cortical model of MS. (C) 2015 Elsevier B.V. All rights reserved.

引用

收藏

页码：68 / 74

页数：7

相关论文

共 19 条

[1]

In Vivo PET Imaging Demonstrates Diminished Microglial Activation After Fingolimod Treatment in an Animal Model of Multiple Sclerosis [J].

Airas, Laura ;

Dickens, Alex M. ;

Elo, Petri ;

Marjamaki, Paivi ;

Johansson, Jarkko ;

Eskola, Olli ;

Jones, Paul A. ;

Trigg, William ;

Solin, Olof ;

Haaparanta-Solin, Merja ;

Anthony, Daniel C. ;

Rinne, Juha .

JOURNAL OF NUCLEAR MEDICINE, 2015, 56 (02) :305-310

[2]

TNF-alpha and IFN-gamma-mediated signal transduction pathways: Effects on glial cell gene expression and function [J].

Benveniste, EN ;

Benos, DJ .

FASEB JOURNAL, 1995, 9 (15) :1577-1584

[3]

Cortical lesions in multiple sclerosis [J].

Calabrese, Massimiliano ;

Filippi, Massimo ;

Gallo, Paolo .

NATURE REVIEWS NEUROLOGY, 2010, 6 (08) :438-444

[4]

Lipoic acid inhibits expression of ICAM-1 and VCAM-1 by CNS endothelial cells and T cell migration into the spinal cord in experimental autoimmune encephalomyelitis [J].

Chaudhary, P ;

Marracci, GH ;

Bourdette, DN .

JOURNAL OF NEUROIMMUNOLOGY, 2006, 175 (1-2) :87-96

[5]

Lipoic acid decreases inflammation and confers neuroprotection in experimental autoimmune optic neuritis [J].

Chaudhary, Priya ;

Marracci, Gail ;

Yu, Xiaolin ;

Galipeau, Danielle ;

Morris, Brooke ;

Bourdette, Dennis .

JOURNAL OF NEUROIMMUNOLOGY, 2011, 233 (1-2) :90-96

[6]

Cyclophilin D inactivation protects axons in experimental autoimmune encephalomyelitis, an animal model of multiple sclerosis [J].

Forte, Michael ;

Gold, Bruce G. ;

Marracci, Gail ;

Chaudhary, Priya ;

Basso, Emy ;

Johnsen, Dustin ;

Yu, Xiaolin ;

Fowlkes, Jonathan ;

Bernardi, Paolo ;

Bourdette, Dennis .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (18) :7558-7563

[7]

Cortical grey matter demyelination can be induced by elevated pro-inflammatory cytokines in the subarachnoid space of MOG-immunized rats [J].

Gardner, Christopher ;

Magliozzi, Roberta ;

Durrenberger, Pascal F. ;

Howell, Owain W. ;

Rundle, Jon ;

Reynolds, Richard .

BRAIN, 2013, 136 :3596-3608

[8]

Targeting experimental autoimmune encephalomyelitis lesions to a predetermined axonal tract system allows for refined behavioral testing in an animal model of multiple sclerosis [J].

Kerschensteiner, M ;

Stadelmann, C ;

Buddeberg, BS ;

Merkler, D ;

Bareyre, FM ;

Anthony, DC ;

Linington, C ;

Brück, W ;

Schwab, ME .

AMERICAN JOURNAL OF PATHOLOGY, 2004, 164 (04) :1455-1469

[9]

Alpha lipoic acid inhibits T cell migration into the spinal cord and suppresses and treats experimental autoimmune encephalomyelitis [J].

Marracci, GH ;

Jones, RE ;

McKeon, GP ;

Bourdette, DN .

JOURNAL OF NEUROIMMUNOLOGY, 2002, 131 (1-2) :104-114

[10]

A new focal EAE model of cortical demyelination:: multiple sclerosis-like lesions with rapid resolution of inflammation and extensive remyelination [J].

Merkler, Doron ;

Ernsting, Tristan ;

Kerschensteiner, Martin ;

Brueck, Wolfgang ;

Stadelmann, Christine .

BRAIN, 2006, 129 :1972-1983