Pharmacologic and behavioral withdrawal from addictive drugs

被引:53
作者
Baker, Timothy B. [1 ]
Japuntich, Sandra J. [1 ]
Hogle, Joanne M. [1 ]
McCarthy, Danielle E. [1 ]
Curtin, John J. [1 ]
机构
[1] Univ Wisconsin, Sch Med & Publ Hlth, Ctr Tobacco Res & Intervent, Madison, WI 53711 USA
关键词
smoking; tobacco dependence; tobacco withdrawal; drug withdrawal;
D O I
10.1111/j.1467-8721.2006.00442.x
中图分类号
B84 [心理学];
学科分类号
04 ; 0402 ;
摘要
Recent theories suggest that drug withdrawal does not motivate drug use and relapse. However, data now show that withdrawal produces complex changes over time in at least two symptoms (i.e., negative affect and urges) that are highly predictive of relapse. Evidence suggests that falling levels of the drug in the blood and interruption of the drug self-administration ritual both affect these symptoms. Both of these forms of withdrawal motivate renewed drug use in addicted individuals.
引用
收藏
页码:232 / 236
页数:5
相关论文
共 14 条
[1]   Addiction motivation reformulated: An affective processing model of negative reinforcement [J].
Baker, TB ;
Piper, ME ;
McCarthy, DE ;
Majeskie, MR ;
Fiore, MC .
PSYCHOLOGICAL REVIEW, 2004, 111 (01) :33-51
[2]   The neurobiology of tobacco dependence: A preclinical perspective on the role of the dopamine projections to the nucleus [J].
Balfour, DJK .
NICOTINE & TOBACCO RESEARCH, 2004, 6 (06) :899-912
[3]   SMOKING WITHOUT NICOTINE DELIVERY DECREASES WITHDRAWAL IN 12-HOUR ABSTINENT SMOKERS [J].
BUTSCHKY, MF ;
BAILEY, D ;
HENNINGFIELD, JE ;
PICKWORTH, WB .
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1995, 50 (01) :91-96
[4]   Cue dependency of nicotine self-administration and smoking [J].
Caggiula, AR ;
Donny, EC ;
White, AR ;
Chaudhri, N ;
Booth, S ;
Gharib, MA ;
Hoffman, A ;
Perkins, KA ;
Sved, AF .
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 2001, 70 (04) :515-530
[5]  
CURTIN JJ, 2006, HDB IMPLICIT COGNITI
[6]   Neural correlates of the motivational and somatic components of naloxone-precipitated morphine withdrawal [J].
Frenois, F ;
Cador, M ;
Caillé, S ;
Stinus, L ;
Le Moine, C .
EUROPEAN JOURNAL OF NEUROSCIENCE, 2002, 16 (07) :1377-1389
[7]  
HOGLE J, IN PRESS PSYCHOPHYSI
[8]  
MCCARTHY D, IN PRESS J ABNORMAL
[9]  
MCCARTHY D, RECENT ADV THEORY PR
[10]   IS THE MOTIVATIONAL EFFECT OF OPIATE WITHDRAWAL REFLECTED BY COMMON SOMATIC INDEXES OF PRECIPITATED WITHDRAWAL - A PLACE CONDITIONING STUDY IN THE RAT [J].
MUCHA, RF .
BRAIN RESEARCH, 1987, 418 (02) :214-220