Endocannabinoids and cardiac contractile function: Pathophysiological implications

被引:43
作者
Batkai, Sandor [1 ]
Pacher, Pal [2 ]
机构
[1] NIAAA, Lab Physiol Studies, NIH, Bethesda, MD 20892 USA
[2] NIAAA, Sect Oxidat Stress Tissue Injury, Lab Physiol Studies, NIH, Bethesda, MD 20892 USA
关键词
Cannabinoids; Cardiovascular disease; Cardiac function; Heart failure; Cardiomyopathy; Cirrhosis; Doxorubicin; DOXORUBICIN-INDUCED CARDIOTOXICITY; CANNABINOID RECEPTOR ANTAGONISM; ISCHEMIA-REPERFUSION INJURY; HEPATIC STELLATE CELLS; ACID AMIDE HYDROLASE; CIRRHOTIC RATS; ENDOGENOUS CANNABINOIDS; CARDIOVASCULAR-DISEASE; HEMODYNAMIC PROFILE; VANILLOID RECEPTORS;
D O I
10.1016/j.phrs.2009.04.003
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Endocannabinoids are part of a bioactive lipid signaling system, not only in the central nervous system but also in various peripheral organs. Accumulating evidence implicates dysregulation of the endocannabinoid system (ECS) in the pathogenesis of various cardiovascular diseases, including hypertension, atherosclerosis, myocardial infarction, hemorrhagic or septic shock, heart failure and cardiovascular complications of liver cirrhosis. Even though the benefit of chronic cannabinoid 1 (CB1) receptor blockade with the currently available compounds may not outweigh the risks in chronic conditions such as obesity, modulation of the ECS may hold great therapeutic promise in various cardiovascular conditions/disorders. In this review we will discuss recent advances in understanding the role of CB, receptors and endocannabinoids in the regulation of cardiac function in cirrhotic carchomyopathy and in doxorubicin-induced heart failure. Published by Elsevier Ltd.
引用
收藏
页码:99 / 106
页数:8
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