Galectin-1 is essential in tumor angiogenesis and is a target for antiangiogenesis therapy

被引：391

作者：

Thijssen, Victor L. J. L.

Postel, Ruben

Brandwijk, Ricardo J. M. G. E.

Dings, Ruud P. M.

Nesmelova, Irina

Satijn, Sietske

Verhofstad, Nicole

Nakabeppu, Yusaku

Baum, Linda G.

Bakkers, Jeroen

Mayo, Kevin H.

Poirier, Francoise

Griffioen, Arjan W. ^{[1
]}

机构：

[1] Univ Maastricht, Angiogenesis Lab, GROW, Dept Pathol, NL-6202 AZ Maastricht, Netherlands

[2] Netherlands Inst Dev Biol, Hubrecht Lab, NL-3584 CT Utrecht, Netherlands

[3] Interuniv Cardiol Inst Netherlands, Hubrecht Lab, NL-3584 CT Utrecht, Netherlands

[4] Univ Minnesota, Dept Biochem Mol Biol & Biophys, Minneapolis, MN 55455 USA

[5] Kyushu Univ, Div Neurofunct Genom, Dept Immunobiol & Neurosci, Med Inst Bioregulat, Fukuoka 8128582, Japan

[6] Univ Calif Los Angeles, Sch Med, Dept Pathol & Lab Med, Los Angeles, CA 90095 USA

[7] Univ Paris 06, UMR 7592, Inst Jacques Monod, CNRS, F-75251 Paris, France

[8] Univ Paris 07, UMR 7592, Inst Jacques Monod, CNRS, F-75251 Paris, France

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2006年 / 103卷 / 43期

关键词：

angiostatic therapy; endothelial cell; galectin; tumor models; anginex;

D O I：

10.1073/pnas.0603883103

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We describe that galectin-1 (gal-1) is a receptor for the angiogenesis inhibitor anginex, and that the protein is crucial for tumor angiogenesis. gal-1 is overexpressed in enclothelial cells of different human tumors. Expression knockdown in cultured enclothelial cells inhibits cell proliferation and migration. The importance of gal-1 in angiogenesis is illustrated in the zebrafish model, where expression knockdown results in impaired vascular guidance and growth of dysfunctional vessels. The role of gal-1 in tumor angiogenesis is demonstrated in gal-1 -null mice, in which tumor growth is markedly impaired because of insufficient tumor angiogenesis. Furthermore, tumor growth in gal-1-null mice no longer responds to antiangiogenesis treatment by anginex. Thus, gal-1 regulates tumor angiogenesis and is a target for angiostatic cancer therapy.

引用

页码：15975 / 15980

页数：6

共 48 条

[1] Biochemical and molecular characterization of galectins from zebrafish (Danio rerio):: notochord-specific expression of a prototype galectin during early embryogenesis [J].