Photoremovable protecting groups: reaction mechanisms and applications

被引：545

作者：

Pelliccioli, AP ^{[1
]}

Wirz, J ^{[1
]}

机构：

[1] Univ Basel, Inst Phys Chem, CH-4056 Basel, Switzerland

来源：

PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES | 2002年 / 1卷 / 07期

关键词：

D O I：

10.1039/b200777k

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Photolabile protecting groups enable biochemists to control the release of bioactive compounds in living tissue. 'Caged compounds' (photoactivatable bioagents) have become an important tool to study the events that follow chemical signalling in, e.g., cell biology and the neurosciences. The possibilities are by no means exhausted. Progress will depend on the development of photoremovable protecting groups that satisfy the diverse requirements of new applications-a challenging task for photochemists.

引用

页码：441 / 458

页数：18

共 177 条

[1] CAGED CYCLIC ADP-RIBOSE - SYNTHESIS AND USE
AARHUS, R
GEE, K
LEE, HC
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (13) : 7745 - 7749
[2] Kinetics of local helix formation in poly-L-glutamic acid studied by time-resolved photoacoustics: Neutralization reactions of carboxylates in aqueous solutions and their relevance to the problem of protein folding
Abbruzzetti, S
Viappiani, C
Small, JR
Libertini, LJ
Small, EW
[J]. BIOPHYSICAL JOURNAL, 2000, 79 (05) : 2714 - 2721
[3] Kinetics of histidine deligation from the heme in GuHCl-unfolded Fe(III) cytochrome c studied by a laser-induced pH-jump technique
Abbruzzetti, S
Viappiani, C
Small, JR
Libertini, LJ
Small, EW
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2001, 123 (27) : 6649 - 6653
[4] Photoinduced alkaline pH-jump on the nanosecond time scale
Abbruzzetti, S
Carcelli, M
Pelagatti, P
Rogolino, D
Viappiani, C
[J]. CHEMICAL PHYSICS LETTERS, 2001, 344 (3-4) : 387 - 394
[5] Fast events in protein folding:: Structural volume changes accompanying the early events in the N→I transition of apomyoglobin induced by ultrafast pH jump
Abbruzzetti, S
Crema, E
Masino, L
Vecli, A
Viappiani, C
Small, JR
Libertini, LJ
Small, EW
[J]. BIOPHYSICAL JOURNAL, 2000, 78 (01) : 405 - 415
[6] A new caged Ca2+, azid-1, is far more photosensitive than nitrobenzyl-based chelators
Adams, SR
LevRam, V
Tsien, RY
[J]. CHEMISTRY & BIOLOGY, 1997, 4 (11): : 867 - 878
[7] ADAMS SR, 1993, ANNU REV PHYSIOL, V55, P755, DOI 10.1146/annurev.physiol.55.1.755
[8] BIOLOGICALLY USEFUL CHELATORS THAT RELEASE CA-2+ UPON ILLUMINATION
ADAMS, SR
KAO, JPY
GRYNKIEWICZ, G
MINTA, A
TSIEN, RY
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1988, 110 (10) : 3212 - 3220
[9] Photo-mediated gene activation using caged RNA/DNA in zebrafish embryos
Ando, H
Furuta, T
Tsien, RY
Okamoto, H
[J]. NATURE GENETICS, 2001, 28 (04) : 317 - 325
[10] Kinetics of the phosphorylation of Na,K-ATPase by inorganic phosphate detected by a fluorescence method
Apell, HJ
Roudna, M
Corrie, JET
Trentham, DR
[J]. BIOCHEMISTRY, 1996, 35 (33) : 10922 - 10930

← 1 2 3 4 5 6 7 8 9 10 →