"Lean" NAFLD: Metabolic Obesity with Normal BMI... Is It in the Genes?

被引：16

作者：

Argo, Curtis K. ^{[1
]}

Henry, Zachary H. ^{[1
]}

机构：

[1] Univ Virginia, Dept Med, Div Gastroenterol & Hepatol, JPA & Lee St,POB 800708, Charlottesville, VA 22908 USA

来源：

AMERICAN JOURNAL OF GASTROENTEROLOGY | 2017年 / 112卷 / 01期

关键词：

FATTY LIVER-DISEASE; PREVALENCE; NONOBESE; RISK;

D O I：

10.1038/ajg.2016.527

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

100201 [内科学];

摘要：

Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease. "Lean" NAFLD represents a patient subpopulation with hepatic steatosis evident on imaging with normal BMI. This paper by Feldman and Eder et al. illustrates the mild but clear metabolic differences and genetic connections in Caucasian lean NAFLD patients compared with obese NAFLD and healthy controls. Their findings highlight key similarities of lean and obese NAFLD compared with lean healthy subjects. This paper characterizes "lean" NAFLD as a unique phenotype with specific genetic associations deserving of further investigation in the greater scheme of elucidating the pathophysiology of fatty liver.

引用

页码：111 / 113

页数：3

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