Mechanisms of enzymatic C-O bond cleavages in deoxyhexose biosynthesis

被引：70

作者：

He, XM ^{[1
]}

Liu, HW ^{[1
]}

机构：

[1] Univ Texas, Coll Pharm, Dept Chem & Biochem, Div Med Chem, Austin, TX 78712 USA

来源：

CURRENT OPINION IN CHEMICAL BIOLOGY | 2002年 / 6卷 / 05期

关键词：

D O I：

10.1016/S1367-5931(02)00367-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In the past few years, significant progress has been made in our understanding of the biosynthesis of deoxyhexoses. Mechanistic studies have revealed how enzymes can cleave C-O bonds of a hexose substrate to make unusual sugars. The increasing amount of knowledge about the biosynthesis of deoxysugars may allow the assembly of a repertoire of novel sugar structures through recruitment and collaborative action of genes from a variety of biosynthetic pathways to create diverse secondary metabolites in our search for novel antibiotic/antitumour agents.

引用

页码：590 / 597

页数：8

共 40 条

[31] Radical SAM, a novel protein superfamily linking unresolved steps in familiar biosynthetic pathways with radical mechanisms: functional characterization using new analysis and information visualization methods [J].

Sofia, HJ ;

Chen, G ;

Hetzler, BG ;

Reyes-Spindola, JF ;

Miller, NE .

NUCLEIC ACIDS RESEARCH, 2001, 29 (05) :1097-1106

[32] Protein radicals in enzyme catalysis [J].

Stubbe, J ;

van der Donk, WA .

CHEMICAL REVIEWS, 1998, 98 (02) :705-762

[33] CHARACTERIZATION OF THE 1ST PMP-DEPENDENT IRON SULFUR-CONTAINING ENZYME WHICH IS ESSENTIAL FOR THE BIOSYNTHESIS OF 3,6-DIDEOXYHEXOSES [J].

THORSON, JS ;

LIU, HW .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1993, 115 (16) :7539-7540

[34]

WANG SF, 1970, J BIOL CHEM, V245, P8

[35] MECHANISTIC AND STEREOCHEMICAL STUDIES OF A UNIQUE DEHYDRATION CATALYZED BY CDP-4-KETO-6-DEOXY-D-GLUCOSE-3-DEHYDRASE - A PYRIDOXAMINE 5'-PHOSPHATE DEPENDENT ENZYME ISOLATED FROM YERSINIA-PSEUDOTUBERCULOSIS [J].

WEIGEL, TM ;

MILLER, VP ;

LIU, HW .

BIOCHEMISTRY, 1992, 31 (07) :2140-2147

[36] The role of carbohydrates in biologically active natural products [J].

WeymouthWilson, AC .

NATURAL PRODUCT REPORTS, 1997, 14 (02) :99-110

[37] A gene cluster for macrolide antibiotic biosynthesis in Streptomyces venezuelae:: Architecture of metabolic diversity [J].

Xue, YQ ;

Zhao, LS ;

Liu, HW ;

Sherman, DH .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (21) :12111-12116

[38]

YU Y, 1992, J BIOL CHEM, V267, P5868

[39] Biosynthesis of desosamine:: Molecular evidence suggesting β-glucosylation as a self-resistance mechanism in Methymycin/Neomethymycin producing strain, Streptomyces venezuelae [J].

Zhao, L ;

Sherman, DH ;

Liu, HW .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1998, 120 (36) :9374-9375

[40] Study of C-4 deoxygenation in the biosynthesis of desosamine: Evidence implicating a novel mechanism [J].

Zhao, LS ;

Borisova, S ;

Yeung, SM ;

Liu, HW .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2001, 123 (32) :7909-7910

← 1 2 3 4 →