Pathogenesis of amyotrophic lateral sclerosis: a critical review

被引：23

作者：

Bromberg, MB ^{[1
]}

机构：

[1] Univ Utah, Dept Neurol, Salt Lake City, UT 84132 USA

来源：

CURRENT OPINION IN NEUROLOGY | 1999年 / 12卷 / 05期

关键词：

D O I：

10.1097/00019052-199910000-00012

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Amyotrophic lateral sclerosis is a neurodegenerative disease with unknown pathogenesis. It is a relatively common disorder of adults (2-4 per 100 000 incidence) and leads to death from respiratory failure. There is no cure at this time, and available treatment and management can at best extend survival to a modest degree. Increasing our understanding of the pathogenesis of this disease is essential to the development of more effective treatments. The level of research interest is very high, and yearly reviews of the literature are helpful in assessing progress. Curr Opin Neurol 12:581-588; (C) 1999 Lippincott Williams & Wilkins.

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页码：581 / 588

页数：8

相关论文

共 51 条

[1] Deletions of the heavy neurofilament subunit tail in amyotrophic lateral sclerosis [J].

Al-Chalabi, A ;

Andersen, PM ;

Nilsson, P ;

Chioza, B ;

Andersson, JL ;

Russ, C ;

Shaw, CE ;

Powell, JF ;

Leigh, PN .

HUMAN MOLECULAR GENETICS, 1999, 8 (02) :157-164

[2] Recessive amyotrophic lateral sclerosis families with the D90A SOD1 mutation share a common founder:: evidence for a linked protective factor [J].

Al-Chalabi, A ;

Andersen, PM ;

Chioza, B ;

Shaw, C ;

Sham, PC ;

Robberecht, W ;

Matthijs, G ;

Camu, V ;

Marklund, SL ;

Forsgren, L ;

Rouleau, G ;

Laing, NG ;

Hurse, PV ;

Siddique, T ;

Leigh, PN ;

Powell, JF .

HUMAN MOLECULAR GENETICS, 1998, 7 (13) :2045-2050

[3] THE ROLE OF CALCIUM-BINDING PROTEINS IN SELECTIVE MOTONEURON VULNERABILITY IN AMYOTROPHIC-LATERAL-SCLEROSIS [J].

ALEXIANU, ME ;

HO, BK ;

MOHAMED, AH ;

LABELLA, V ;

SMITH, RG ;

APPEL, SH .

ANNALS OF NEUROLOGY, 1994, 36 (06) :846-858

[4] Autosomal recessive adult-onset amyotrophic lateral sclerosis associated with homozygosity for Asp90Ala CuZn-superoxide dismutase mutation - A clinical and genealogical study of 36 patients [J].

Andersen, PM ;

Forsgren, L ;

Binzer, M ;

Nilsson, P ;

AlaHurula, V ;

Keranen, ML ;

Bergmark, L ;

Saarinen, A ;

Haltia, T ;

Tarvainen, I ;

Kinnunen, E ;

Udd, B ;

Marklund, SL .

BRAIN, 1996, 119 :1153-1172

[5] Mutations in the glutamate transporter EAAT2 gene do not cause abnormal EAAT2 transcripts in amyotrophic lateral sclerosis [J].

Aoki, M ;

Lin, CLG ;

Rothstein, JD ;

Geller, BA ;

Hosler, BA ;

Munsat, TL ;

Horvitz, HR ;

Brown, RH .

ANNALS OF NEUROLOGY, 1998, 43 (05) :645-653

[6] Beneficial effects of lysine acetylsalicylate, a soluble salt of aspirin, on motor performance in a transgenic model of amyotrophic lateral sclerosis [J].

Barnéoud, P ;

Curet, O .

EXPERIMENTAL NEUROLOGY, 1999, 155 (02) :243-251

[7] Increased 3-nitrotyrosine in both sporadic and familial amyotrophic lateral sclerosis [J].

Beal, MF ;

Ferrante, RJ ;

Browne, SE ;

Matthews, RT ;

Kowall, NW ;

Brown, RH .

ANNALS OF NEUROLOGY, 1997, 42 (04) :644-654

[8]

Beal MF, 1999, ANN NEUROL, V45, P414, DOI 10.1002/1531-8249(199903)45:3<414::AID-ANA25>3.0.CO

[9]

2-1

[10] EL-ESCORIAL WORLD FEDERATION OF NEUROLOGY CRITERIA FOR THE DIAGNOSIS OF AMYOTROPHIC-LATERAL-SCLEROSIS [J].

BROOKS, BR .

JOURNAL OF THE NEUROLOGICAL SCIENCES, 1994, 124 :96-107

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