Structural change in living tissues

被引:12
作者
Cowin, SC [1 ]
机构
[1] CUNY City Coll, Ctr Biomed Engn, New York, NY 10031 USA
[2] CUNY Grad Sch & Univ Ctr, New York, NY 10031 USA
[3] Sch Engn, Dept Mech Engn, New York, NY USA
关键词
mechanics of the development of biological structures; biomechanics;
D O I
10.1023/A:1004777501507
中图分类号
O3 [力学];
学科分类号
08 ; 0801 ;
摘要
Tissues change in many ways in the period that they are part of a living organism. Tissues are created in fairly repeatable structural patterns, and the patterns are due to both the genes and the (mechanical) environment, but we do not know exactly what part or percentage of a particular pattern to consider the genes, or the environment, responsible for. We do not know much about the beginning of tissue construction (morphogenesis) and also the methods of tissue construction. When the tissue structure is altered to accommodate a new loading, it is not known how the decision is made for the structural reconstruction. We know that tissues grow or reconstruct themselves without ceasing to continue with their structural function, but we do not understand the processes that permit them to accomplish this. Tissues change their structures to altered mechanical environments, but we are not sure how. Tissues heal themselves and we understand little of the structural mechanics of the process. With the objective of describing the interesting unsolved mechanics problems associated with these biological processes, some aspects of the formation, growth and adaptation of living tissues are reviewed. Beyond the objective is the hope that the work will stimulate new ideas and new observations in developmental biology.
引用
收藏
页码:379 / 398
页数:20
相关论文
共 36 条
[1]  
[Anonymous], DEV CELL BIOL SERIES
[2]  
[Anonymous], MONOGRAPHS DEV BIOL
[3]  
[Anonymous], 2010, DYNAMIC ARCHITECTURE
[4]  
BAER E, 1992, PHYSICS TODAY OCT, P60
[5]  
Bard J., 1990, DEV CELL BIOL SERIES, V23
[6]   On mechanosensation in bone under microgravity [J].
Cowin, SC .
BONE, 1998, 22 (05) :119S-125S
[7]  
GiraudGuille MM, 1996, INT REV CYTOL, V166, P59, DOI 10.1016/S0074-7696(08)62506-1
[8]   LIQUID CRYSTALLINITY IN CONDENSED TYPE-I COLLAGEN SOLUTIONS - A CLUE TO THE PACKING OF COLLAGEN IN EXTRACELLULAR MATRICES [J].
GIRAUDGUILLE, MM .
JOURNAL OF MOLECULAR BIOLOGY, 1992, 224 (03) :861-873
[9]   Expression of pattern in plants: Combining molecular and calculus-based biophysical paradigms [J].
Green, PB .
AMERICAN JOURNAL OF BOTANY, 1999, 86 (08) :1059-1076
[10]   Phyllotactic patterns: A biophysical mechanism for their origin [J].
Green, PB ;
Steele, CS ;
Rennich, SC .
ANNALS OF BOTANY, 1996, 77 (05) :515-527