Molecular Pathogenesis of Cutaneous Melanocytic Neoplasms

被引：89

作者：

Ibrahim, Nageatte ^{[1
]}

Haluska, Frank G. ^{[2
]}

机构：

[1] Massachusetts Gen Hosp, Ctr Canc, Boston, MA 02114 USA

[2] ARIAD Pharmaceut Inc, Cambridge, MA 02139 USA

来源：

ANNUAL REVIEW OF PATHOLOGY-MECHANISMS OF DISEASE | 2009年 / 4卷

关键词：

melanoma genetics; familial melanoma; BRAF; MAPK pathway; CDKN2A; apoptosis; CELL-CYCLE ARREST; C-KIT EXPRESSION; FACTOR RECEPTOR PROTOONCOGENE; TRANSCRIPTION FACTOR GENE; KINASE-4 INHIBITOR GENE; MELANOMA-PRONE FAMILIES; PHASE-II TRIAL; MALIGNANT-MELANOMA; METASTATIC MELANOMA; GERMLINE MUTATIONS;

D O I：

10.1146/annurev.pathol.3.121806.151541

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Melanoma is the deadliest form of skin cancer without an effective treatment. An understanding of the genetic basis of melanoma has recently shed light on some of the mechanisms of melanomagenesis. This review explores the major genes involved in familial and sporadic Cutaneous melanoma with an emphasis on CDKN2A, CDK4, MC1R, and MAPK pathway targets (e.g., RAS and BRAF), apoptosis regulators (e.g., BCL-2, AKT, and APAF-1),and the tumor-suppressor genes TP53 and PTEN. New directions for therapeutics based on our current knowledge of the genes implicated in melanoma are also discussed.

引用

页码：551 / 579

页数：29

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