Predicted acetylcholine layer around embryonic motoneurones

被引:5
作者
Limozin, L
Pelce, P
Savtchenko, L
Chamoin, MC
Ternaux, JP
机构
[1] UNIV AIX MARSEILLE 1,IRPHE BIOPHYS,F-13397 MARSEILLE 20,FRANCE
[2] LAB NEUROCYBERNET CELLULAIRE,CNRS,UPR 9041,F-13009 MARSEILLE,FRANCE
[3] DNIEPROPETROVSK STATE UNIV,LAB BIOPHYS & BIOELECT,UA-320625 DNEPROPETROV,UKRAINE
关键词
acetylcholine secretion; acetylcholinesterase; diffusion; morphogenesis; purified motoneurones; screening length;
D O I
10.1097/00001756-199709080-00030
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
THE secretion of acetylcholine (ACh) from cultures of dissociated rat purified embryonic motoneurones into the medium was measured at different times using a chemiluminescent assay. From these results it is proposed that a motoneurone is able to generate an extracellular ACh layer surrounding its membrane. This layer is expected to modulate the ACh concentration at the membrane in a range where ACh receptors can be sensitive, and thus to affect the response of the motoneurone. The influences of both membrane-bound and soluble-secreted acetylcholinesterase (AChE) were simulated and a local ACh membrane efflux was deduced. Since ACh usually exerts an inhibitory effect on neurite outgrowth, a possible autocrine influence of the ACh layer in motoneurone morphogenesis is discussed.
引用
收藏
页码:2957 / 2960
页数:4
相关论文
共 23 条
[1]   A BDNF AUTOCRINE LOOP IN ADULT SENSORY NEURONS PREVENTS CELL DEATH [J].
ACHESON, A ;
CONOVER, JC ;
FANDL, JP ;
DECHIARA, TM ;
RUSSELL, M ;
THADANI, A ;
SQUINTO, SP ;
YANCOPOULOS, GD ;
LINDSAY, RM .
NATURE, 1995, 374 (6521) :450-453
[2]   ACETYLCHOLINESTERASE DENSITY AND TURNOVER NUMBER AT FROG NEUROMUSCULAR-JUNCTIONS, WITH MODELING OF THEIR ROLE IN SYNAPTIC FUNCTION [J].
ANGLISTER, L ;
STILES, JR ;
SALPETER, MM .
NEURON, 1994, 12 (04) :783-794
[3]  
BIAGIONI S, 1995, J NEUROCHEM, V64, P1528
[4]   Open channel block by physostigmine and procaine in embryonic-like nicotinic receptors of mouse muscle [J].
Bufler, J ;
Franke, C ;
Parnas, H ;
Dudel, J .
EUROPEAN JOURNAL OF NEUROSCIENCE, 1996, 8 (04) :677-687
[5]   PHYSICAL-MECHANISMS UNDERLYING NEURITE OUTGROWTH - A QUANTITATIVE-ANALYSIS OF NEURONAL SHAPE [J].
CASERTA, F ;
STANLEY, HE ;
ELDRED, WD ;
DACCORD, G ;
HAUSMAN, RE ;
NITTMANN, J .
PHYSICAL REVIEW LETTERS, 1990, 64 (01) :95-98
[6]   Numerical simulation of cellular tip growth [J].
Denet, B .
PHYSICAL REVIEW E, 1996, 53 (01) :986-992
[7]   A NEW AND RAPID COLORIMETRIC DETERMINATION OF ACETYLCHOLINESTERASE ACTIVITY [J].
ELLMAN, GL ;
COURTNEY, KD ;
ANDRES, V ;
FEATHERSTONE, RM .
BIOCHEMICAL PHARMACOLOGY, 1961, 7 (02) :88-&
[8]   CELLULAR-LOCALIZATION OF THE MOLECULAR-FORMS OF ACETYLCHOLINESTERASE IN PRIMARY CULTURES OF RAT SYMPATHETIC NEURONS AND ANALYSIS OF THE SECRETED ENZYME [J].
FERRAND, C ;
CLAROUS, D ;
DELTEIL, C ;
WEBER, MJ .
JOURNAL OF NEUROCHEMISTRY, 1986, 46 (02) :349-358
[9]   PRESSURE EJECTION OF ACETYLCHOLINESTERASE WITHIN THE GUINEA-PIG SUBSTANTIA NIGRA HAS NON-CLASSICAL ACTIONS ON THE PARS COMPACTA CELLS INDEPENDENT OF SELECTIVE RECEPTOR AND ION CHANNEL BLOCKADE [J].
GREENFIELD, SA ;
NEDERGAARD, S ;
WEBB, C ;
FRENCH, M .
NEUROSCIENCE, 1989, 29 (01) :21-25
[10]   Synthesis and release of an acetylcholine-like compound by human myoblasts and myotubes [J].
Hamann, M ;
Chamoin, MC ;
Portalier, P ;
Bernheim, L ;
Baroffio, A ;
Widmer, H ;
Bader, CR ;
Ternaux, JP .
JOURNAL OF PHYSIOLOGY-LONDON, 1995, 489 (03) :791-803