High fat diet aggravates arsenic induced oxidative stress in rat heart and liver

被引：47

作者：

Dutta, Mousumi ^{[1
,3
]}

Ghosh, Debosree ^{[1
]}

Ghosh, Arnab Kumar ^{[1
]}

Bose, Gargi ^{[1
]}

Chattopadhyay, Aindrila ^{[3
]}

Rudra, Smita ^{[1
]}

Dey, Monalisa ^{[1
]}

Bandyopadhyay, Arkita ^{[1
]}

Pattari, Sanjib K. ^{[4
]}

Mallick, Sanjaya ^{[5
]}

Bandyopadhyay, Debasish ^{[1
,2
]}

机构：

[1] Univ Calcutta, Univ Coll Sci & Technol, Dept Physiol, Oxidat Stress & Free Radical Biol Lab, Kolkata 700009, India

[2] Univ Calcutta, Univ Coll Sci & Technol, CPEPA, Kolkata 700009, India

[3] Vidyasagar Coll, Dept Physiol, Kolkata 700006, India

[4] RN Tagore Int Inst Cardiac Sci, Kolkata 700099, India

[5] Univ Calcutta, Achaiya Prafulla Chandra Sikhsha Prangan, Kolkata 700098, India

来源：

FOOD AND CHEMICAL TOXICOLOGY | 2014年 / 66卷

关键词：

Arsenic; Oxidative stress; High fat diet; Heart damage; Liver damage; MELATONIN PROTECTS; GLUTATHIONE-PEROXIDASE; LIPID-PEROXIDATION; MYOCARDIAL INJURY; NITRIC-OXIDE; WEST-BENGAL; ISOPROTERENOL; SUPEROXIDE; METALS; DAMAGE;

D O I：

10.1016/j.fct.2014.01.050

中图分类号：

TS2 [食品工业];

学科分类号：

100403 [营养与食品卫生学];

摘要：

Arsenic is a well known global groundwater contaminant. Exposure of human body to arsenic causes various hazardous effects via oxidative stress. Nutrition is an important susceptible factor which can affect arsenic toxicity by several plausible mechanisms. Development of modern civilization led to alteration in the lifestyle as well as food habits of the people both in urban and rural areas which led to increased use of junk food containing high level of fat. The present study was aimed at investigating the effect of high fat diet on heart and liver tissues of rats when they were co-treated with arsenic. This study was established by elucidating heart weight to body weight ratio as well as analysis of the various functional markers, oxidative stress biomarkers and also the activity of the antioxidant enzymes. Histological analysis confirmed the biochemical investigations. From this study it can be concluded that high fat diet increased arsenic induced oxidative stress. (C) 2014 Elsevier Ltd. All rights reserved.

引用

页码：262 / 277

页数：16

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[1]

Melatonin protects against piroxicam-induced gastric ulceration [J].