mRNA vaccines - a new era in vaccinology

被引：3075

作者：

Pardi, Norbert ^{[1
]}

Hogan, Michael J. ^{[1
]}

Porter, Frederick W. ^{[2
]}

Weissman, Drew ^{[1
]}

机构：

[1] Univ Penn, Dept Med, Philadelphia, PA 19104 USA

[2] Duke Univ, Duke Human Vaccine Inst, Sch Med, Durham, NC 27710 USA

来源：

NATURE REVIEWS DRUG DISCOVERY | 2018年 / 17卷 / 04期

基金：

美国国家卫生研究院;

关键词：

T-CELL RESPONSES; ELECTROPORATED DENDRITIC CELLS; CONSTITUTIVELY ACTIVE TLR4; ANTIGEN-PRESENTING CELLS; CXC CHEMOKINE RECEPTOR-5; TUMOR-ASSOCIATED ANTIGEN; ACUTE MYELOID-LEUKEMIA; INFLUENZA-A VIRUS; IMMUNE-RESPONSES; ANTITUMOR IMMUNITY;

D O I：

10.1038/nrd.2017.243

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 [微生物学]; 090105 [作物生产系统与生态工程];

摘要：

mRNA vaccines represent a promising alternative to conventional vaccine approaches because of their high potency, capacity for rapid development and potential for low-cost manufacture and safe administration. However, their application has until recently been restricted by the instability and inefficient in vivo delivery of mRNA. Recent technological advances have now largely overcome these issues, and multiple mRNA vaccine platforms against infectious diseases and several types of cancer have demonstrated encouraging results in both animal models and humans. This Review provides a detailed overview of mRNA vaccines and considers future directions and challenges in advancing this promising vaccine platform to widespread therapeutic use.

引用

页码：261 / 279

页数：19

共 221 条

[1]

Vaccination with mRNA-Electroporated Dendritic Cells Induces Robust Tumor Antigen-Specific CD4+ and CD8+ T Cells Responses in Stage III and IV Melanoma Patients [J].

Aarntzen, Erik H. J. G. ;

Schreibelt, Gerty ;

Bol, Kalijn ;

Lesterhuis, W. Joost ;

Croockewit, Alexandra J. ;

de Wilt, Johannes H. W. ;

van Rossum, Michelle M. ;

Blokx, Willeke A. M. ;

Jacobs, Joannes F. M. ;

Duiveman-de Boer, Tjitske ;

Schuurhuis, Danita H. ;

Mus, Roel ;

Thielemans, Kris ;

de Vries, I. Jolanda M. ;

Figdor, Carl G. ;

Punt, Cornelis J. A. ;

Adema, Gosse J. .

CLINICAL CANCER RESEARCH, 2012, 18 (19) :5460-5470

[2]

Humoral and cellular immune response to RNA immunization with flavivirus Replicons derived from tick-borne encephalitis virus [J].

Aberle, JH ;

Aberle, SW ;

Kofler, RA ;

Mandl, CW .

JOURNAL OF VIROLOGY, 2005, 79 (24) :15107-15113

[3]

CD83 expression on dendritic cells and T cells: Correlation with effective immune responses [J].

Aerts-Toegaert, Cindy ;

Heirman, Carlo ;

Tuyaerts, Sandra ;

Corthals, Jurgen ;

Aerts, Joeri L. ;

Bonehill, Aude ;

Thielemans, Kris ;

Breckpot, Karine .

EUROPEAN JOURNAL OF IMMUNOLOGY, 2007, 37 (03) :686-695

[4]

Targeted Delivery of RNAi Therapeutics With Endogenous and Exogenous Ligand-Based Mechanisms [J].

Akinc, Akin ;

Querbes, William ;

De, Soma ;

Qin, June ;

Frank-Kamenetsky, Maria ;

Jayaprakash, K. Narayanannair ;

Jayaraman, Muthusamy ;

Rajeev, Kallanthottathil G. ;

Cantley, William L. ;

Dorkin, J. Robert ;

Butler, James S. ;

Qin, LiuLiang ;

Racie, Timothy ;

Sprague, Andrew ;

Fava, Eugenio ;

Zeigerer, Anja ;

Hope, Michael J. ;

Zerial, Marino ;

Sah, Dinah W. Y. ;

Fitzgerald, Kevin ;

Tracy, Mark A. ;

Manoharan, Muthiah ;

Koteliansky, Victor ;

de Fougerolles, Antonin ;

Maier, Martin A. .

MOLECULAR THERAPY, 2010, 18 (07) :1357-1364

[5]

Safety and immunogenicity of a mRNA rabies vaccine in healthy adults: an open-label, non-randomised, prospective, first-in-human phase 1 clinical trial [J].

Alberer, Martin ;

Gnad-Vogt, Ulrike ;

Hong, Henoch Sangjoon ;

Mehr, Keyvan Tadjalli ;

Backert, Linus ;

Finak, Greg ;

Gottardo, Raphael ;

Bica, Mihai Alexandru ;

Garofano, Aurelio ;

Koch, Sven Dominik ;

Fotin-Mleczek, Mariola ;

Hoerr, Ingmar ;

Clemens, Ralf ;

von Sonnenburg, Frank .

LANCET, 2017, 390 (10101) :1511-1520

[6]

Aldevron, 2016, ALD EXP N DAK BIOM F

[7]

A phase I/IIa immunotherapy trial of HIV-1-infected patients with Tat, Rev and Nef expressing dendritic cells followed by treatment interruption [J].

Allard, Sabine D. ;

De Keersmaecker, Brenda ;

de Goede, Anna L. ;

Verschuren, Esther J. ;

Koetsveld, Jeanette ;

Reedijk, Mariska L. ;

Wylock, Carolien ;

De Bel, Annelies V. ;

Vandeloo, Judith ;

Pistoor, Frank ;

Heirman, Carlo ;

Beyer, Walter E. P. ;

Eilers, Paul H. C. ;

Corthals, Jurgen ;

Padmos, Iman ;

Thielemans, Kris ;

Osterhaus, Albert D. M. E. ;

Lacor, Patrick ;

van der Ende, Marchina E. ;

Aerts, Joeri L. ;

van Baalen, Carel A. ;

Gruters, Rob A. .

CLINICAL IMMUNOLOGY, 2012, 142 (03) :252-268

[8]

Survival with AGS-003, an autologous dendritic cell-based immunotherapy, in combination with sunitinib in unfavorable risk patients with advanced renal cell carcinoma (RCC): Phase 2 study results [J].

Amin, Asim ;

Dudek, Arkadiusz Z. ;

Logan, Theodore F. ;

Lance, Raymond S. ;

Holzbeierlein, Jeffrey M. ;

Knox, Jennifer J. ;

Master, Viraj A. ;

Pal, Sumanta K. ;

Miller, Wilson H., Jr. ;

Karsh, Lawrence I. ;

Tcherepanova, Irina Y. ;

DeBenedette, Mark A. ;

Williams, W. Lee ;

Plessinger, Douglas C. ;

Nicolette, Charles A. ;

Figlin, Robert A. .

JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2015, 3

[9]

Nucleoside modifications in RNA limit activation of 2'-5'-oligoadenylate synthetase and increase resistance to cleavage by RNase L [J].

Anderson, Bart R. ;

Muramatsu, Hiromi ;

Jha, Babal K. ;

Silverman, Robert H. ;

Weissman, Drew ;

Kariko, Katalin .

NUCLEIC ACIDS RESEARCH, 2011, 39 (21) :9329-9338

[10]

Incorporation of pseudouridine into mRNA enhances translation by diminishing PKR activation [J].

Anderson, Bart R. ;

Muramatsu, Hiromi ;

Nallagatla, Subba R. ;

Bevilacqua, Philip C. ;

Sansing, Lauren H. ;

Weissman, Drew ;

Kariko, Katalin .

NUCLEIC ACIDS RESEARCH, 2010, 38 (17) :5884-5892

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