Topoisomerases in kinetoplastids

被引：38

作者：

Burri, C

Bodley, AL

Shapiro, TA

机构：

[1] Department of Medicine, Johns Hopkins Univ. Sch. of Medicine, 301 Hunterian Building, Baltimore, MD 21205-2185

来源：

PARASITOLOGY TODAY | 1996年 / 12卷 / 06期

基金：

新加坡国家研究基金会;

关键词：

D O I：

10.1016/0169-4758(96)10017-X

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Topoisomerases are enzymes that mediate topological changes in DNA that are essential for nucleic acid biosynthesis and for cell survival. The kinetoplastid protozoa, which include pathogenic trypanosomes and Leishmania, have yielded an interesting variety of purified topoisomerase activities as well as several topoisomerase genes. In these parasites, topoisomerases are involved in the metabolism of both nuclear and mitochondrial (kinetoplast) DNA. In this review, Christian Burri, Annette Bodley and Theresa Shapiro summarize what is known about topoisomerases in kinetoplastids, and consider the intriguing possibility that these enzymes may act as valuable antiparasite drug targets.

引用

页码：226 / 231

页数：6

共 61 条

[1] FIGHTING PARASITES ON A SHOESTRING [J].

ALDHOUS, P .

SCIENCE, 1994, 264 (5167) :1857-1859

[2] RNA EDITING IN TRYPANOSOMES [J].

BENNE, R .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 1994, 221 (01) :9-23

[3]

BETBEDER D, 1988, Medical Science Research, V16, P141

[4] ANTITRYPANOSOMAL ACTIVITY OF CAMPTOTHECIN ANALOGS - STRUCTURE-ACTIVITY CORRELATIONS [J].

BODLEY, AL ;

WANI, MC ;

WALL, ME ;

SHAPIRO, TA .

BIOCHEMICAL PHARMACOLOGY, 1995, 50 (07) :937-942

[5] MOLECULAR AND CYTOTOXIC EFFECTS OF CAMPTOTHECIN, A TOPOISOMERASE-I INHIBITOR, ON TRYPANOSOMES AND LEISHMANIA [J].

BODLEY, AL ;

SHAPIRO, TA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (09) :3726-3730

[6]

Caron P R, 1994, Adv Pharmacol, V29B, P271

[7] MODE OF ACTION OF PENTAVALENT ANTIMONIALS - SPECIFIC-INHIBITION OF TYPE-I DNA TOPOISOMERASE OF LEISHMANIA-DONOVANI [J].

CHAKRABORTY, AK ;

MAJUMDER, HK .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1988, 152 (02) :605-611

[8] DECATENATION OF KINETOPLAST DNA BY AN ATP-DEPENDENT DNA TOPOISOMERASE FROM THE KINETOPLAST HEMOFLAGELLATE LEISHMANIA-DONOVANI [J].

CHAKRABORTY, AK ;

MAJUMDER, HK .

MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 1987, 26 (03) :215-224

[9]

CHAKRABORTY AK, 1993, INDIAN J BIOCHEM BIO, V30, P257

[10] AN ATP-INDEPENDENT CATENATING ENZYME FROM THE KINETOPLAST HEMOFLAGELLATE LEISHMANIA-DONOVANI [J].

CHAKRABORTY, AK ;

MAJUMDER, HK .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1991, 180 (01) :279-285

← 1 2 3 4 5 6 7 →