Characterization of adenylate cyclase-hemolysin gene duplication in a Bordetella pertussis isolate

被引：14

作者：

Dalet, K

Weber, C

Guillemot, L

Njamkepo, E

Guiso, N

机构：

[1] Inst Pasteur, Unite Prevent & Therapie Mol Malad Humaines, F-75724 Paris 15, France

[2] Inst Pasteur, Unite Postulante Biol Cellulaire Parasitisme, F-75724 Paris 15, France

来源：

INFECTION AND IMMUNITY | 2004年 / 72卷 / 08期

关键词：

D O I：

10.1128/IAI.72.8.4874-4877.2004

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We describe a clinical isolate of Bordetella pertussis, the agent responsible for whooping cough, composed of at least two clones harboring one or two copies of the cya locus encoding one of the major toxins, adenylate cyclase-hemolysin. No difference was observed between the two clones in murine and cellular models, probably due to the high instability of the cya locus duplication.

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页码：4874 / 4877

页数：4

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