B cell positive selection: Road map to the primary repertoire?

被引:72
作者
Cancro, MP
Kearney, AE
机构
[1] Univ Penn, Sch Med, Dept Pathol, Philadelphia, PA 19104 USA
[2] Univ Alabama Birmingham, Dept Microbiol, Div Dev & Clin Immunol, Birmingham, AL 35294 USA
关键词
D O I
10.4049/jimmunol.173.1.15
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Accumulating evidence indicates that positive selection events mediate differentiation, lineage commitment, and longevity of B lymphocytes. The BCR plays a central role, dictating the likelihood that newly formed cells will complete maturation, as well as whether cells persist within mature pools. Competition among B cells for limited, life span-promoting resources, which include self-ligands, lineage-specific cytokines, and innate receptor ligands, underlie these selective processes. Together, these observations suggest that positive selection is a critical feature in the establishment and maintenance of all lymphocyte pools, prompting re-evaluation of the underlying biological rationale for this process.
引用
收藏
页码:15 / 19
页数:5
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