Direct and indirect immunosuppression by a malaria parasite in its mosquito vector

被引:33
作者
Boëte, C
Paul, REL
Koella, JC
机构
[1] Univ Paris 06, Lab Parasitol Evolutive, CNRS, UMR 7103, F-75252 Paris 05, France
[2] Inst Pasteur, Unite Biochim & Biol Mol Insectes, F-75724 Paris 15, France
关键词
immunosuppression; insect immunity; malaria; Aedes aeopti; Plasmodium gallinaceum;
D O I
10.1098/rspb.2004.2762
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Malaria parasites develop as oocysts within the haemocoel of their mosquito vector during a period that is longer than the average lifespan of many of their vectors. How can they escape from the mosquito's immune responses during their long development? Whereas older oocysts might camouflage themselves by incorporating mosquito-derived proteins into their surface capsule, younger stages are susceptible to the mosquito's immune response and must rely on other methods of immune evasion. We show that the malaria parasite Plasmodium gallinaceum suppresses the encapsulation immune response of its mosquito vector, Aedes aegypti, and in particular that the parasite uses both an indirect and a direct strategy for immunosuppression. Thus, when we fed mosquitoes with the plasma of infected chickens, the efficacy of the mosquitoes to encapsulate negatively charged Sephadex beads was considerably reduced, whether the parasite was present in the blood meal or not. In addition, zygotes that were created ex vivo and added to the blood of uninfected chickens reduced the efficacy of the encapsulation response. As dead zygotes had no effect on encapsulation, this result demonstrates active suppression of the mosquito's immune response by malaria parasites.
引用
收藏
页码:1611 / 1615
页数:5
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