Nationwide survey of in vitro activities of itraconazole and voriconazole against clinical Aspergillus fumigatus isolates cultured between 1945 and 1998

被引:71
作者
Verweij, PE
Dorsthorst, DTAT
Rijs, AJMM
De Vries-Hospers, HG
Meis, JFGM
机构
[1] Univ Nijmegen, Med Ctr, Dept Med Microbiol, NL-6500 HB Nijmegen, Netherlands
[2] Canisius Wilhelmina Hosp, Dept Med Microbiol & Infect Dis, Nijmegen, Netherlands
[3] Univ Groningen Hosp, Dept Med Microbiol, Groningen, Netherlands
关键词
D O I
10.1128/JCM.40.7.2648-2650.2002
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
The isolates in a collection of 170 Aspergillus fumigatus isolates recovered from 114 patients and 21 different medical centers in The Netherlands over a period of 53 years were tested for the presence of resistance to itraconazole and voriconazole according to the guidelines of NCCLS document M38-P and by the E-test. Three isolates were highly resistant to itraconazole, and voriconazole MICs were low for all isolates.
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页码:2648 / 2650
页数:3
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