Role of the melanocortin system in inflammation

被引：31

作者：

Maaser, Christian ^{[1
]}

Kannengiesser, Klaus ^{[1
]}

Kucharzik, Torsten ^{[1
]}

机构：

[1] Univ Munster, Dept Med B, D-4400 Munster, Germany

来源：

INFLAMMATORY BOWEL DISEASE: GENETICS, BARRIER FUNCTION, IMMUNOLOGIC MECHANISMS, AND MICROBIAL PATHWAYS | 2006年 / 1072卷

关键词：

colitis; MSH; melanocortin; KPV; intestinum;

D O I：

10.1196/annals.1326.016

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

In recent years, scientific interest in melanocortins (MC) has progressively increased due to their wide range of effects and expression on various tissues. Primarily discovered as mediators of skin pigmentation, recent research has shown their important roles in various body functions, such as energy homeostasis, sexual function, and inflammation. The anti-inflammatory and immunomodulatory properties discovered so far have led to the hypothesis that alpha-melanocyte-stimulating hormone (MSH) and its cognate receptors might present potential anti-inflammatory treatment options.

引用

页码：123 / 134

页数：12

共 66 条

[1]

Adachi S, 1999, J IMMUNOL, V163, P3363

[2] MC1 receptors are constitutively expressed on leucocyte subpopulations with antigen presenting and cytotoxic functions [J].