Dietary supplementation of arachidonic acid is associated with higher whole body weight and bone mineral density in growing pigs

被引:62
作者
Weiler, HA [1 ]
机构
[1] Univ Manitoba, Dept Food & Nutr, Winnipeg, MB R3T 2N2, Canada
关键词
D O I
10.1203/00006450-200005000-00022
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
Essential fatty acids are fundamental to normal growth and development, but North American formulas do not contain arachidonic (AA) and docosahexaenoic acid (DHA). The main objective of the present study was to determine whether addition of AA and DHA to formula elevates growth and bone mineralization in piglets. A secondary objective was to establish whether liver fatty acid composition is related to that of bone. Twelve 10-d-old male piglets were randomized to receive either a standard formula with an n-6:n-3 fatty acid ratio of 4.9:1.0 or the same formula made with an equal amount of fat but containing AA (0.5% wt/wt total fat) and DHA (0.1% wt/wt total fat) for 14 d. Piglets in the supplemented group had significantly (p < 0.05) higher weight and greater bone mineral density of the whole body, lumbar spine, and femur. No differences were observed in whole body length, calcium absorption, or biochemical markers of bone metabolism. Feeding AA resulted in lower linoleic acid (p < 0.05) and higher (p < 0.05) AA in liver total lipid (% wt/wt) and bone FFA (% wt/wt) but no change to DHA. Liver AA (% wt/wt total lipid) was positively related (p < 0.05) to growth, free AA (% wt/wt) in bone, bone mineral content, bone mineral density, and urinary prostaglandin E-2 but negatively related (p < 0.05) to free linoleic acid in bone. Inverse relationships were observed when liver linoleic acid was substituted for liver AA as the independent variable. These data indicate that feeding AA is associated with elevated weight and higher whole body and regional bone mineral density.
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页码:692 / 697
页数:6
相关论文
共 29 条
[1]   FATTY-ACID COMPOSITION AND ARACHIDONIC-ACID CONCENTRATIONS IN ALVEOLAR BONE OF RATS FED DIETS WITH DIFFERENT LIPIDS [J].
ALAM, SQ ;
KOKKINOS, PP ;
ALAM, BS .
CALCIFIED TISSUE INTERNATIONAL, 1993, 53 (05) :330-332
[2]   DOCOSAHEXAENOIC ACID IN DEVELOPING BRAIN AND RETINA OF PIGLETS FED HIGH OR LOW ALPHA-LINOLENATE FORMULA WITH AND WITHOUT FISH OIL [J].
ARBUCKLE, LD ;
INNIS, SM .
LIPIDS, 1992, 27 (02) :89-93
[3]   Visual acuity, erythrocyte fatty acid composition, and growth in term infants fed formulas with long chain polyunsaturated fatty acids for one year [J].
Auestad, N ;
Montalto, MB ;
Hall, RT ;
Fitzgerald, KM ;
Wheeler, RE ;
Connor, WE ;
Neuringer, M ;
Connor, SL ;
Taylor, JA ;
Hartmann, EE .
PEDIATRIC RESEARCH, 1997, 41 (01) :1-10
[4]   HIGH TURNOVER OSTEOPENIA IN PRETERM BABIES [J].
BEYERS, N ;
ALHEIT, B ;
TALJAARD, JF ;
HALL, JM ;
HOUGH, SF .
BONE, 1994, 15 (01) :5-13
[5]  
*BRADD PRINT SERV, 1993, CAN COUNC AN CAR 199, V1, P34
[6]   The very low birth weight premature infant is capable of synthesizing arachidonic and docosahexaenoic acids from linoleic and linolenic acids [J].
Carnielli, VP ;
Wattimena, DJL ;
Luijendijk, IHT ;
Boerlage, A ;
Degenhart, HJ ;
Sauer, PJJ .
PEDIATRIC RESEARCH, 1996, 40 (01) :169-174
[7]   THE EFFECT OF DIFFERENT N-6 N-3 ESSENTIAL FATTY-ACID RATIOS ON CALCIUM BALANCE AND BONE IN RATS [J].
CLAASSEN, N ;
COETZER, H ;
STEINMANN, CML ;
KRUGER, MC .
PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS, 1995, 53 (01) :13-19
[8]   SUPPLEMENTED GAMMA-LINOLENIC ACID AND EICOSAPENTAENOIC ACID INFLUENCE BONE STATUS IN YOUNG MALE-RATS - EFFECTS ON FREE URINARY COLLAGEN CROSS-LINKS, TOTAL URINARY HYDROXYPROLINE, AND BONE CALCIUM CONTENT [J].
CLAASSEN, N ;
POTGIETER, HC ;
SEPPA, M ;
VERMAAK, WJH ;
COETZER, H ;
VANPAPENDORP, DH ;
KRUGER, MC .
BONE, 1995, 16 (04) :S385-S392
[9]   CALCIUM-TRANSPORT BY ISOLATED BRUSH-BORDER AND BASOLATERAL MEMBRANE-VESICLES - ROLE OF ESSENTIAL FATTY-ACID SUPPLEMENTATION [J].
COETZER, H ;
CLAASSEN, N ;
VANPAPENDORP, DH ;
KRUGER, MC .
PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS, 1994, 50 (05) :257-266
[10]  
DESCOMPS B, 1996, C R SEANCES SOC BIOL, V189, P781