Inflammatory response in patients with active and inactive osteoarthritis

被引：37

作者：

Toncheva, Antoaneta ^{[2
]}

Remichkova, Mimi ^{[1
]}

Ikonomova, Krassimira ^{[3
]}

Dimitrova, Petya ^{[1
]}

Ivanovska, Nina ^{[1
]}

机构：

[1] Bulgarian Acad Sci, Inst Microbiol, Dept Immunol, BU-1113 Sofia, Bulgaria

[2] Natl Transport Hosp, Clin Internal Dis, Sofia, Bulgaria

[3] Natl Transport Hosp, Dept Clin Immunol, Sofia, Bulgaria

来源：

RHEUMATOLOGY INTERNATIONAL | 2009年 / 29卷 / 10期

关键词：

Osteoarthritis; Cytokines; sRANKL; RANTES; MRP8; Neutrophils; MYELOID-RELATED PROTEINS; KAPPA-B-LIGAND; RHEUMATOID-ARTHRITIS; SYNOVIAL-FLUID; RECEPTOR-ACTIVATOR; CARTILAGE DEGRADATION; KNEE OSTEOARTHRITIS; DISEASE-ACTIVITY; MRP; EXPRESSION;

D O I：

10.1007/s00296-009-0864-0

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

In the present study, we have investigated comparatively the inflammatory response of patients with active and inactive osteoarthritis. The sera from 31 healthy individuals, 37 patients with active OA, and 19 patients with inactive OA were assayed for TNF-alpha, IL-6, sRANKL, RANTES, and MRP8 using ELISA in order to evaluate their potential as markers of disease activity. Also, the spontaneous and LSP-induced release of TNF-alpha and IL-6 by peripheral blood neutrophils was determined. The activation of OA is associated with elevated TNF-alpha, IL-6, and RANTES serum levels while sRANKL and MRP8 appeared to be increased in both active and inactive OA. The neutrophil spontaneous and up-regulated by LPS cytokine release can contribute to the exacerbation of OA.

引用

页码：1197 / 1203

页数：7

共 40 条

[1]

Alaaeddine N, 2001, ARTHRITIS RHEUM-US, V44, P1633, DOI 10.1002/1529-0131(200107)44:7<1633::AID-ART286>3.0.CO

[2]

2-Z

[3]

THE AMERICAN-RHEUMATISM-ASSOCIATION 1987 REVISED CRITERIA FOR THE CLASSIFICATION OF RHEUMATOID-ARTHRITIS [J].

ARNETT, FC ;

EDWORTHY, SM ;

BLOCH, DA ;

MCSHANE, DJ ;

FRIES, JF ;

COOPER, NS ;

HEALEY, LA ;

KAPLAN, SR ;

LIANG, MH ;

LUTHRA, HS ;

MEDSGER, TA ;

MITCHELL, DM ;

NEUSTADT, DH ;

PINALS, RS ;

SCHALLER, JG ;

SHARP, JT ;

WILDER, RL ;

HUNDER, GG .

ARTHRITIS AND RHEUMATISM, 1988, 31 (03) :315-324

[4]

Boiardi L, 1999, CLIN EXP RHEUMATOL, V17, P419

[5]

The role of synovial macrophages and macrophage-produced cytokines in driving aggrecanases, matrix metalloproteinases, and other destructive and inflammatory responses in osteoarthritis [J].

Bondeson, Jan ;

Wainwright, Shane D. ;

Lauder, Sarah ;

Amos, Nick ;

Hughes, Clare E. .

ARTHRITIS RESEARCH & THERAPY, 2006, 8 (06)

[6]

BRUN JG, 1994, J RHEUMATOL, V21, P733

[7]

CHATHAM WW, 1993, ARTHRITIS RHEUM, V36, P51

[8]

Novel strategies for the treatment of osteoarthritis [J].

Chikanza, IC ;

Fernandes, L .

EXPERT OPINION ON INVESTIGATIONAL DRUGS, 2000, 9 (07) :1499-1510

[9]

Receptor activator NF-κB ligand (RANKL) expression in synovial tissue from patients with rheumatoid arthritis, spondyloarthropathy, osteoarthritis, and from normal patients:: semiquantitative and quantitative analysis [J].

Crotti, TN ;

Smith, MD ;

Weedon, H ;

Ahern, MJ ;

Findlay, DM ;

Kraan, M ;

Tak, PP ;

Haynes, DR .

ANNALS OF THE RHEUMATIC DISEASES, 2002, 61 (12) :1047-1054

[10]

Involvement of IL-6, apart from its role in immunity, in mediating a chronic response during experimental arthritis [J].

de Hooge, ASK ;

van de Loo, FAJ ;

Arntz, OJ ;

van den Berg, WB .

AMERICAN JOURNAL OF PATHOLOGY, 2000, 157 (06) :2081-2091

← 1 2 3 4 →