Implication of sperm RNAs in transgenerational inheritance of the effects of early trauma in mice

被引：878

作者：

Gapp, Katharina ^{[1
,2
]}

Jawaid, Ali ^{[1
,2
]}

Sarkies, Peter ^{[3
]}

Bohacek, Johannes ^{[1
,2
]}

Pelczar, Pawel ^{[4
]}

Prados, Julien ^{[5
]}

Farinelli, Laurent ^{[5
]}

Miska, Eric ^{[3
]}

Mansuy, Isabelle M. ^{[1
,2
]}

机构：

[1] Univ Zurich, Neurosci Ctr Zurich, Brain Res Inst, Zurich, Switzerland

[2] Swiss Fed Inst Technol, Zurich, Switzerland

[3] Gurdon Inst, Cambridge, England

[4] Univ Zurich, Inst Lab Anim Sci, Zurich, Switzerland

[5] FASTERIS SA, Plan Les Ouates, Switzerland

来源：

NATURE NEUROSCIENCE | 2014年 / 17卷 / 05期

基金：

瑞士国家科学基金会;

关键词：

PROTEIN; EXPRESSION; MICRORNAS; RESPONSES; ALIGNMENT; CLEAVAGE;

D O I：

10.1038/nn.3695

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

Small non-coding RNAs (sncRNAs) are potential vectors at the interface between genes and environment. We found that traumatic stress in early life altered mouse microRNA (miRNA) expression, and behavioral and metabolic responses in the progeny. Injection of sperm RNAs from traumatized males into fertilized wild-type oocytes reproduced the behavioral and metabolic alterations in the resulting offspring.

引用

收藏

页码：667 / +

页数：5

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