Inter-ring directed ortho lithiation by the 2-pyridyl group in bipyridines

被引：18

作者：

Zoltewicz, JA

Dill, CD

机构：

[1] Department of Chemistry, University of Florida, Gainesville

来源：

TETRAHEDRON | 1996年 / 52卷 / 46期

关键词：

lithiation; bipyridines; Pd-catalyzed coupling; terpyridines;

D O I：

10.1016/0040-4020(96)00892-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Kinetically enhanced metallation by the 2-pyridyl group of 2,2'-bipyridine or 2.4'-bipyridine (BPY) in the presence of lithium 2,2,6,6-(tetramethyl)piperidide directs lithiation to the ortho position of the adjacent ring. Representative electrophiles convert the lithiated material to a number of substituted products. The stannylated BPY products were coupled with 9-iodopyridine in the presence of Pd(PPh(3))(4) to give two novel terpyridines. Copyright (C) 1996 Elsevier Science Ltd

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收藏

页码：14469 / 14474

页数：6

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