Synthetic methodologies for C-nucleosides

被引：143

作者：

Wu, QP ^{[1
]}

Simons, C

机构：

[1] Beijing Inst Technol, Sch Life Sci & Technol, Beijing 100081, Peoples R China

[2] Cardiff Univ, Welsh Sch Pharm, Cardiff CF10 3XF, S Glam, Wales

来源：

SYNTHESIS-STUTTGART | 2004年 / 10期

关键词：

C-nucleosides; organometallic reagents; Heck-type reaction; anticancer; antiviral;

D O I：

10.1055/s-2004-829106

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The study and synthesis of C-nucleosides has been extensive owing to their biological activity and potential as drug candidates for antiviral and anticancer therapy. Numerous synthetic strategies have also been investigated in order to optimize yields and stereoselectivity in the glycosylation reaction. Here we review one class of synthetic methods, direct condensation of a pre-formed aglycon unit with an appropriate sugar component.

引用

页码：1533 / 1553

页数：21

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