Effects of luteolin and other flavonoids on IgE-mediated allergic reactions

被引：131

作者：

Kimata, M ^{[1
]}

Inagaki, N ^{[1
]}

Nagai, H ^{[1
]}

机构：

[1] Gifu Pharmaceut Univ, Dept Pharmacol, Gifu 5028585, Japan

来源：

PLANTA MEDICA | 2000年 / 66卷 / 01期

关键词：

flavonoids; luteolin; biphasic cutaneous reaction; mast cells; anti-allergic activity;

D O I：

10.1055/s-2000-11107

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The anti-allergic action of luteolin was investigated in the rodent experimental allergic models. In the present study, the effects of luteolin were compared to those of baicalein, quercetin, and prednisolone. Luteolin as well as baicalein, quercetin, and prednisolone inhibited the IgE antibody-mediated biphasic cutaneous reaction (immediate phase reaction and late phase reaction) in mice. However, these compounds did not affect the histamine; serotonin-, and platelet activating factor-induced cutaneous reactions in rats. In an in vitro study, luteolin, baicalein, and quercetin inhibited IgE-mediated histamine release from bone marrow-derived cultured murine mast cells (BMMC) and rat peritoneal mast cells. These compounds also inhibited IgE-mediated TNF-alpha and IL-6 production from BMMC. From these results, luteolin inhibited the IgE-mediated biphasic cutaneous reaction mainly by the inhibition of histamine and cytokine release from mast cells, but not through mediator antagonistic effects.

引用

页码：25 / 29

页数：5

共 23 条

[1] Relationship between flavonoid structure and inhibition of phosphatidylinositol 3-kinase: A comparison with tyrosine kinase and protein kinase C inhibition [J].