Occupational Complexity and Cognitive Reserve in a Middle-Aged Cohort at Risk for Alzheimer's Disease

被引：104

作者：

Boots, Elizabeth A. ^{[1
,2
]}

Schultz, Stephanie A. ^{[1
,2
]}

Almeida, Rodrigo P. ^{[1
,2
,3
]}

Oh, Jennifer M. ^{[1
,2
]}

Koscik, Rebecca L. ^{[4
]}

Dowling, Maritza N. ^{[2
,5
]}

Gallagher, Catherine L. ^{[1
,2
,6
]}

Carlsson, Cynthia M. ^{[1
,2
]}

Rowley, Howard A. ^{[2
,7
]}

Bendlin, Barbara B. ^{[1
,2
,4
]}

Asthana, Sanjay ^{[1
,2
,4
]}

Sager, Mark A. ^{[2
,4
]}

Hermann, Bruce P. ^{[2
,4
]}

Johnson, Sterling C. ^{[1
,2
,4
]}

Okonkwo, Ozioma C. ^{[1
,2
,4
]}

机构：

[1] William S Middleton Mem Vet Adm Med Ctr, Geriatr Res Educ & Clin Ctr, Madison, WI 53705 USA

[2] Univ Wisconsin, Sch Med & Publ Hlth, Wisconsin Alzheimers Dis Res Ctr, Madison, WI 53792 USA

[3] Univ Fed Fluminense, BR-24220 Niteroi, RJ, Brazil

[4] Univ Wisconsin, Sch Med & Publ Hlth, Wisconsin Alzheimers Inst, Madison, WI 53705 USA

[5] Univ Wisconsin, Sch Med & Publ Hlth, Dept Biostat & Med Informat, Madison, WI 53792 USA

[6] Univ Wisconsin, Sch Med & Publ Hlth, Dept Neurol, Madison, WI 53705 USA

[7] Univ Wisconsin, Sch Med & Publ Hlth, Dept Radiol, Madison, WI 53792 USA

来源：

ARCHIVES OF CLINICAL NEUROPSYCHOLOGY | 2015年 / 30卷 / 07期

关键词：

Alzheimer's disease; Occupation; Cognitive reserve; Hippocampus; Cognition; Imaging; SURFACE-BASED ANALYSIS; PITTSBURGH COMPOUND-B; LIFETIME OCCUPATION; EMISSION-TOMOGRAPHY; WISCONSIN-REGISTRY; BRAIN VOLUME; EDUCATION; DECLINE; DEMENTIA; ADULTS;

D O I：

10.1093/arclin/acv041

中图分类号：

B849 [应用心理学];

学科分类号：

040203 [应用心理学];

摘要：

Higher occupational attainment has previously been associated with increased Alzheimer's disease (AD) neuropathology when individuals are matched for cognitive function, indicating occupation could provide cognitive reserve. We examined whether occupational complexity (OCC) associates with decreased hippocampal volume and increased whole-brain atrophy given comparable cognitive function in middle-aged adults at risk for AD. Participants (n = 323) underwent structural MRI, cognitive evaluation, and work history assessment. Three complexity ratings (work with data, people, and things) were obtained, averaged across up to 3 reported jobs, weighted by years per job, and summed to create a composite OCC rating. Greater OCC was associated with decreased hippocampal volume and increased whole-brain atrophy when matched for cognitive function; results remained substantively unchanged after adjusting for several demographic, AD risk, vascular, mental health, and socioeconomic characteristics. These findings suggest that, in people at risk for AD, OCC may confer resilience to the adverse effects of neuropathology on cognition.

引用

页码：634 / 642

页数：9

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