Zinc transporters and the cellular trafficking of zinc

被引：672

作者：

Eide, David J. ^{[1
]}

机构：

[1] Univ Wisconsin, Dept Nutr Sci, Madison, WI 53706 USA

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH | 2006年 / 1763卷 / 07期

基金：

美国国家科学基金会; 美国国家卫生研究院;

关键词：

zinc; cell biology; transporters; ZIP; CDF;

D O I：

10.1016/j.bbamcr.2006.03.005

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Zinc is an essential nutrient for all organisms because this metal serves as a catalytic or structural cofactor for many different proteins. Zinc-dependent proteins are found in the cytoplasm and within many organelles of the eukaryotic cell including the nucleus, the endoplasmic reticulum, Golgi, secretory vesicles, and mitochondria. Thus, cells require zinc transport mechanisms to allow cells to efficiently accumulate the metal ion and distribute it within the cell. Our current knowledge of these transport systems in eukaryotes is the focus of this review. (c) 2006 Elsevier B.V. All rights reserved.

引用

页码：711 / 722

页数：12

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