The hedgehog signaling pathway in cancer

被引：197

作者：

Evangelista, Marie ^{[1
]}

Tian, Hua ^{[1
]}

de Sauvage, Frederic J. ^{[1
]}

机构：

[1] Genentech Inc, Dept Mol Biol, San Francisco, CA 94080 USA

来源：

CLINICAL CANCER RESEARCH | 2006年 / 12卷 / 20期

关键词：

D O I：

10.1158/1078-0432.CCR-06-1736

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The Hedgehog (H h) pathway is a signaling cascade that directs patterning in most animals and is crucial for proper development. At the molecular level, Hh ligands drive cell proliferation in some cell types while causing others to undergo differentiation. Hh signaling is most active during embryogenesis, and aberrant reactivation of the pathway in adult tissue can lead to the development of cancer. A comprehensive understanding of Hh signaling during development will undoubtedly shed light into the mechanism of Hh in cancer progression and identify potential targets for therapeutic intervention.

引用

页码：5924 / 5928

页数：5

共 66 条

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