Antibacterial cobalt(II), nickel(II) and zinc(II) complexes of nicotinic acid-derived Schiff-bases

被引：40

作者：

Chohan, ZH

Rauf, A

Noreen, S

Scozzafava, A

Supuran, CT

机构：

[1] Univ Florence, Dipartimento Chim, Lab Chim Bioinorgan, I-50019 Sesto Fiorentino, Firenze, Italy

[2] Islamia Univ, Dept Chem, Bahawalpur, Pakistan

来源：

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY | 2002年 / 17卷 / 02期

关键词：

antibacterial derivative; nicotinic acid; Schiff base; metal cornplex;

D O I：

10.1080/14756360290024209

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

Nicotinic acid derived Schiff bases and their transition metal [cobalt(II), nickel(II) and zinc(II)] complexes have been prepared and characterized by physical, spectral and analytical data. The Schiff bases act as deprotonated tridentate ligands for the complexation of the above mentioned metal ions. These complexes, possessing the general formula [M(L)(2)] [where M = Co(II), Ni(II) and Zn(II) and L = HL1 -HL4] showed an octahedral geometry of the metal ions. For determining the effect of metal ions upon chelation, the Schiff bases and their complexes have been screened for antibacterial activity against several pathogenic strains of Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa. The new metal derivatives reported here were more bactericidal against one or more bacterial species as compared to the uncomplexed Schiff bases.

引用

页码：101 / 106

页数：6

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