Prostatic Intraepithelial neoplasia in genetically engineered mice

被引:145
作者
Park, JH
Walls, JE
Galvez, JJ
Kim, MJ
Abate-Shen, C
Shen, MM
Cardiff, RD
机构
[1] Univ Calif Davis, Ctr Comparat Med, Davis, CA 95616 USA
[2] Univ Calif Davis, Dept Med Pathol, Davis, CA 95616 USA
[3] UMDNJ Robert Wood Johnson Med Sch, Ctr Adv Biotechnol & Med, Dept Neurosci, Piscataway, NJ USA
[4] UMDNJ Robert Wood Johnson Med Sch, Ctr Adv Biotechnol & Med, Dept Pediat, Piscataway, NJ USA
[5] Seoul Natl Univ, Coll Vet Med, Lab Anim Med, Suwon, South Korea
关键词
D O I
10.1016/S0002-9440(10)64228-9
中图分类号
R36 [病理学];
学科分类号
100104 ;
摘要
Several mouse models of human prostate cancer were studied to identify and characterize potential precursor lesions containing foci of atypical epithelial cells. These lesions exhibit a sequence of changes suggesting progressive evolution toward malignancy. Based on these observations, a grading system is proposed to classify prostatic intraepithelial neoplasia (PIN) in genetically engineered mice (GEM). Four grades of GEM PIN are proposed based on their architecture, differentiation pattern, and degree of cytological atypia. PIN I lesions have one or two layers of atypical cells. PIN H has two or more layers of atypical cells. PIN III has large, pleomorphic nuclei with prominent nucleoli and the cells tend to involve the entire lumen with expansion of the duct outlines. PIN IV lesions contain atypical cells that fill the lumen and bulge focally into, and frequently compromise, the fibromuscular sheath. Within the same cohorts, the lower grade PINs first appear earlier than the higher grades. Morphometric and immunohistochemical analyses confirm progressive change. Although the malignant potential of PIN IV in mice has not been proven, GEM PIN is similar to human PIN. This PIN classification system is a first step toward a systematic evaluation of the biological potential of these lesions in GEM.
引用
收藏
页码:727 / 735
页数:9
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